4-Morpholinecarboxylic acid, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, 1,1-dimethylethyl ester, (2S)-

Base Information

• Chemical Name: 4-Morpholinecarboxylic acid, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, 1,1-dimethylethyl ester, (2S)-
• CAS No.: 847805-34-9
• Molecular Formula: C24H31NO5
• Molecular Weight: 413.514
• Mol file: 847805-34-9.mol

Synonyms:

Chemical Property of 4-Morpholinecarboxylic acid, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, 1,1-dimethylethyl ester, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Morpholinecarboxylic acid, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, 1,1-dimethylethyl ester, (2S)-

There total 18 articles about 4-Morpholinecarboxylic acid, 2-[(S)-(2-ethoxyphenoxy)phenylmethyl]-, 1,1-dimethylethyl ester, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-32-7) + η6-(1-ethoxy-2-fluorobenzene)tricarbonylchromium (847900-05-4) → (+)-(2S,3S)-2-[α-(2-ethoxyphenoxy)phenylmethyl]morpholine-4-carboxylic acid tert-butyl ester (847805-34-9)

Guidance literature:

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester; η⁶-(1-ethoxy-2-fluorobenzene)tricarbonylchromium; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With iodine; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Reference yield: 95.0%

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester (847805-32-7) → (+)-(2S,3S)-2-[α-(2-ethoxyphenoxy)phenylmethyl]morpholine-4-carboxylic acid tert-butyl ester (847805-34-9)

Guidance literature:

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester; o-FC₆H₄OEt*Cr(CO)3; With sodium hydride; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 2h;

With iodine; In hexane; N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

DOI:10.1021/ol050059g

Reference yield: 72.0%

2-Ethoxyphenol (94-71-3) + C16H22BrNO3 (1016544-97-0) → (+)-(2S,3S)-2-[α-(2-ethoxyphenoxy)phenylmethyl]morpholine-4-carboxylic acid tert-butyl ester (847805-34-9)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 25 ℃; Inert atmosphere;

DOI:10.1039/c0cc00650e

upstream raw materials:

(+)-(2S,3R)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

2-Ethoxyphenol

(+)-(2S,3S)-2-[α-hydroxy(phenyl)methyl]morpholine-4-carboxylic acid tert-butyl ester

(2R,3S)-1-bromo-3-phenylpropane-2,3-diol

Downstream raw materials:

(S,S)-reboxetine