4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid

Base Information

Chemical Name:4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid
CAS No.:849235-68-3
Molecular Formula:C17H14N4O2
Molecular Weight:306.324
Hs Code.:2933990090
Mol file:849235-68-3.mol

Synonyms:4-(([4-(pyridin-3-yl)pyrimidin-2-yl]amino)methyl)benzoic acid;4-((4-(propoxy)phenyl)sulfonyl)phenol;Phenol,4-[(4-propoxyphenyl)sulfonyl];4-n-propoxy-4'-hydroxydiphenyl sulfone;

Suppliers and Price of 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid >97%
500mg
$ 548.00

Crysdot
4-(((4-(Pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzoicacid 95+%
1g
$ 646.00

AK Scientific
4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoicacid
500mg
$ 789.00

Total 2 raw suppliers

Chemical Property of 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid

Chemical Property:

Boiling Point:608.2±65.0 °C(Predicted)
PKA:4.24±0.10(Predicted)
PSA：88.00000
Density:1.348±0.06 g/cm3(Predicted)
LogP:2.92190

Purity/Quality:

99% ^*data from raw suppliers

4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid >97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid

There total 8 articles about 4-({[4-(Pyridin-3-yl)pyrimidin-2-yl]amino}methyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 736080-30-1
4-guanidinomethylbenzoic acid methyl ester

: 55314-16-4,75415-01-9,123367-26-0
(E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one

: 849235-68-3
4-(([4-(pyridin-3-yl)pyrimidin-2-yl]amino)methyl)benzoic acid

Guidance literature:: 4-guanidinomethylbenzoic acid methyl ester; (E)-3-(dimethylamino)-1-(pyridin-3-yl)prop-2-en-1-one; With sodium methylate; In methanol; for 48h; Reflux;

With water; sodium hydroxide; In methanol; for 23h; Reflux;

Reference yield: 97.0%

: 849235-67-2
methyl 4-(((4-(pyridin-3-yl)pyrimidin-2-yl)amino)methyl)benzoate

: 849235-68-3
4-(([4-(pyridin-3-yl)pyrimidin-2-yl]amino)methyl)benzoic acid

Guidance literature:: With water; lithium hydroxide; at 20 ℃; for 24h;
DOI:10.1021/jm400634n

Reference yield:

: 66521-66-2
4-pyridin-3-ylpyrimidin-2-ylamine

: 849235-68-3
4-(([4-(pyridin-3-yl)pyrimidin-2-yl]amino)methyl)benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.25 h / Cooling with ice

1.2: 6 h

2.1: sodium hydroxide; water / methanol / 2 h / 20 °C

With water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/c5md00247h