2(1H)-Pyridinone,4-hydroxy-5,6-dimethyl-

Base Information

• Chemical Name: 2(1H)-Pyridinone,4-hydroxy-5,6-dimethyl-
• CAS No.: 84953-72-0
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Hs Code.: 2933399090
• Mol file: 84953-72-0.mol

Synonyms:2,4-dihydroxy-5,6-dimethylpyridine;5,6-Dimethyl-pyridin-2,4-diol;5,6-dimethyl-pyridine-2,4-diol;

Chemical Property of 2(1H)-Pyridinone,4-hydroxy-5,6-dimethyl-

Chemical Property:

• Melting Point: 350 °C(Solv: water (7732-18-5))
• Boiling Point: 304.1±42.0 °C(Predicted)
• PKA: 12.96±0.10(Predicted)
• PSA: 53.35000
• Density: 1.194±0.06 g/cm3(Predicted)
• LogP: 1.10960
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-5,6-dimethylpyridin-2(1H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2(1H)-Pyridinone,4-hydroxy-5,6-dimethyl-

There total 6 articles about 2(1H)-Pyridinone,4-hydroxy-5,6-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester (77629-51-7) → 4-hydroxy-5,6-dimethylpyridin-2(1H)-one (84953-72-0)

Guidance literature:

4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester; With sodium hydroxide; In water; for 2h; Heating;

With hydrogenchloride; at 0 ℃; pH=7;

DOI:10.1021/ol0357503

Reference yield:

4-hydroxy-5,6-dimethyl-2H-pyran-2-one (50405-45-3) → 5,6-dimethylpyridine-2,4-diol (84953-72-0)

Guidance literature:

With ammonia; In 1,4-dioxane;

Reference yield:

ethyl (3E)-3-[(3-methoxy-3-oxopropanoyl)imino]-2-methylbutanoate (629673-22-9) → 4-hydroxy-5,6-dimethylpyridin-2(1H)-one (84953-72-0)

Guidance literature:

ethyl (3E)-3-[(3-methoxy-3-oxopropanoyl)imino]-2-methylbutanoate; With sodium hydride; In tetrahydrofuran; for 3h; Heating / reflux;

With methanol;

With hydrogenchloride; ammonia; more than 3 stages;

upstream raw materials:

Ethyl 2,4-Dihydroxy-5,6-dimethylnicotinate

4-hydroxy-5,6-dimethyl-2H-pyran-2-one

4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester

2-acetylpropanoic acid ethyl ester

Downstream raw materials:

4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester

4-bromo-2-methoxy-5,6-dimethylpyridin-3-amine

4-bromo-6-methoxy-2,3-dimethylpyridine

methyl 6-methoxy-4-(3,4-dimethoxy-2-(methoxymethoxy)phenyl)-3-methyl-5-nitropyridine-2-carboxylate