77629-51-7

Usage

Chemical Properties

Off-White Solid

Upstream product

• 54393-21-4 ethyl 3-amino-2-methyl-2-butenoate 
• 105-53-3 diethyl malonate 
• 84953-72-0 4-hydroxy-5,6-dimethylpyridin-2(1H)-one 
• 64-17-5 ethanol 
• 609-14-3 2-acetylpropanoic acid ethyl ester 
• 14369-90-5 Ethyl 3-amino-2-methyl-2-butenoate 

Downstream Products

• 84953-72-0 5,6-dimethylpyridine-2,4-diol 
• 84953-72-0 4-hydroxy-5,6-dimethylpyridin-2(1H)-one 
• 640721-52-4 4-bromo-2-methoxy-5,6-dimethylpyridin-3-amine 
• 640721-49-9 4-bromo-5,6-dimethyl-2(1H)-pyridinone 
• 640721-50-2 4-bromo-6-methoxy-2,3-dimethylpyridine 
• 905557-17-7 methyl 6-methoxy-4-(3,4-dimethoxy-2-(methoxymethoxy)phenyl)-3-methyl-5-nitropyridine-2-carboxylate 
• 905557-10-0 (4-bromo-6-methoxy-3-methylpyridin-2-yl)methyl acetate 
• 101252-84-0 4,6-dichloro-2,3-dimethyl-pyridine 
• 583-61-9 2,3-Lutidine 
• 77629-53-9 ethyl 5,6-dimethyl-3-pyridinecarboxylate 

Relevant academic research and scientific papers

Process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide

The invention discloses a process method for producing 3-ethyl formate-4-hydroxy-2-pyridone by utilizing carbon dioxide. The process method comprises the following steps: weighing a 4-hydroxy-6-alkyl-2-pyridone substrate, a catalyst and potassium tert-butoxide to be added into a Schleck bottle, degassing, and continuously introducing 1atm of carbon dioxide; adding a solvent, and reacting in an oilbath; performing after-treatment after the reaction is completed so as to obtain a 3-carboxyl-4-hydroxy-2-pyridone compound 2; carrying out an esterification reaction among the obtained compound 2,(1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), 2-methylaminopyridine and ethanol; performing column chromatography isolation after the reaction is completed, thereby obtaining the 3-ethyl formate-4-hydroxy-2-pyridone 3. According to the process method disclosed by the invention, the used catalyst is wide in source and low in price; the preparation process is simple, the equipment requirement is low, the raw material is wide in source and low in cost, the toxicity is low, and industrial scale-up production is easily realized.

Siloxane-Based Cross-Coupling of Bromopyridine Derivatives: Studies for the Synthesis of Streptonigrin and Lavendamycin

(Equation Presented) Highly functionalized 4-bromopyridines were prepared and found to undergo fluoride-promoted, Pd-catalyzed cross-coupling with aryltrialkoxy-silanes to give sterically demanding biaryls. The 3-nitro-4-bromopyridine derivative coupled i

Steric and Conformational Effects in Nicotine Chemistry

The stereoselectivity of iodomethylation of nicotine and seven nicotine analogues having pyridine alkyl groups was determined by using 13C NMR.Alkylation at the pyridine (N) and at the pyrrolidine (N') nitrogens was observed.Two modes of N'-iodomethylation occur, cis and trans to the pyridine ring.N'-Iodomethylation occurs regioselectively cis to the pyridine ring for all compounds examined.The N/N' and N'cis/N'trans ratios for the nicotinoids were evaluated with regard to (1) the orientation of the N'-methyl group in the free base, (2) conformational properties of the pyridine ring with respect to the pyrrolidine ring, and (3) steric hindrance and buttressing effects on the pyridine nitrogen.The Curtin-Hammett principle and the Winstein-Holness equation are used to analyse reactions.