3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester

Base Information

• Chemical Name: 3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester
• CAS No.: 77629-51-7
• Molecular Formula: C10H13 N O4
• Molecular Weight: 211.218
• Hs Code.: 2933399090
• Mol file: 77629-51-7.mol

Synonyms:2,4-Dihydroxy-5,6-dimethylnicotinicacid ethyl ester

Chemical Property of 3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester

Chemical Property:

• PSA: 79.65000
• LogP: 1.28630
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform, Dichloromethane

Purity/Quality:

97% ^*data from raw suppliers

2,4-Dihydroxy-5,6-dimethylNicotinicAcidEthylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester

There total 6 articles about 3-Pyridinecarboxylic acid,1,2-dihydro-4-hydroxy-5,6-dimethyl-2-oxo-,ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

ethanol (64-17-5) + C8H9NO4 → 4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester (77629-51-7)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In toluene; at 50 ℃; for 16h; Green chemistry;

Reference yield: 65.0%

ethyl 3-amino-2-methyl-2-butenoate (54393-21-4) + diethyl malonate (105-53-3) → 4-hydroxy-5,6-dimethyl-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid ethyl ester (77629-51-7)

Guidance literature:

diethyl malonate; With ethanol; sodium; In toluene; for 1h;

ethyl 3-amino-2-methyl-2-butenoate; In ethanol; toluene; for 96h; Heating;

DOI:10.1021/ol0357503

Reference yield: 51.0%

ethyl 3-amino-2-methyl-2-butenoate (54393-21-4) + diethyl malonate (105-53-3) → Ethyl 2,4-Dihydroxy-5,6-dimethylnicotinate (77629-51-7)

Guidance literature:

With sodium ethanolate; In ethanol; at 140 ℃; for 9h; Parr bomb;

DOI:10.1021/jo00328a010

upstream raw materials:

Ethyl 3-amino-2-methyl-2-butenoate

diethyl malonate

ethyl 3-amino-2-methyl-2-butenoate

2-acetylpropanoic acid ethyl ester

Downstream raw materials:

5,6-dimethylpyridine-2,4-diol

ethyl 5,6-dimethyl-3-pyridinecarboxylate

2,3-Lutidine

4,6-dichloro-2,3-dimethyl-pyridine

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