(2R)-2-(Benzyloxy)-3-methylbutan-1-ol

Base Information

• Chemical Name: (2R)-2-(Benzyloxy)-3-methylbutan-1-ol
• CAS No.: 84994-63-8
• Molecular Formula: C12H18O2
• Molecular Weight: 194.274
• DSSTox Substance ID: DTXSID10534907
• Wikidata: Q82408959
• Mol file: 84994-63-8.mol

Synonyms:84994-63-8;(2R)-2-(Benzyloxy)-3-methylbutan-1-ol;DTXSID10534907

Chemical Property of (2R)-2-(Benzyloxy)-3-methylbutan-1-ol

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 194.130679813
• Heavy Atom Count: 14
• Complexity: 139

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C(CO)OCC1=CC=CC=C1
• Isomeric SMILES: CC(C)[C@H](CO)OCC1=CC=CC=C1

Technology Process of (2R)-2-(Benzyloxy)-3-methylbutan-1-ol

There total 15 articles about (2R)-2-(Benzyloxy)-3-methylbutan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methyl (R)-2-benzyloxy-3-methylbutanoate (90211-83-9) → (R)-2-benzyloxy-3-methyl-1-butanol (84994-63-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; for 0.5h;

DOI:10.1016/S0040-4020(01)82419-4

Reference yield: 92.0%

methyl 2-benzyloxy-3-methylbutanoate (110351-27-4) → 2-Benzyloxy-3-methyl-butan-1-ol (84994-63-8,129919-92-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1021/jo00068a047

Reference yield:

2-(Benzyloxy)-3-methylbutanal (96925-01-8) → (S)-2-(benzyloxy)-3-methylbutane-1-ol (129919-92-2) + (R)-2-benzyloxy-3-methyl-1-butanol (84994-63-8)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at -75 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/cl.1983.93

upstream raw materials:

3-phenyl-propionaldehyde

C-methyl-C,N-bis(trimethylsilyl)ketenimine

methyl (R)-2-benzyloxy-3-methylbutanoate

2-(Benzyloxy)-3-methylbutanal

Downstream raw materials:

(2R)-benzyloxy-3-methyl-1-iodobutane

2-(Benzyloxy)-3-methylbutanal

(4R*)-Methyl 4-(benzyloxy)-2--5-methyl-(2E)-hexenoate

(4R*)-Methyl 4-(benzyloxy)-2--5-methyl-(2Z)-hexenoate