129919-92-2

Basic information

• Product Name: (S)-2-(benzyloxy)-3-methylbutane-1-ol
• Synonyms: (S)-2-(benzyloxy)-3-methylbutane-1-ol
• CAS NO: 129919-92-2
• Molecular Weight: 194.274
• Mol File: 129919-92-2.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (S)-2-(benzyloxy)-3-methylbutane-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-(benzyloxy)-3-methylbutane-1-ol(129919-92-2)
• EPA Substance Registry System: (S)-2-(benzyloxy)-3-methylbutane-1-ol(129919-92-2)

Safety Data

• Hazardous Substances Data: 129919-92-2(Hazardous Substances Data)

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 31650-03-0 C-methyl-C,N-bis(trimethylsilyl)ketenimine 
• 96925-01-8 2-(Benzyloxy)-3-methylbutanal 
• 391871-69-5 (S)-2-(benzyloxy)-3-methylbutanoic acid 
• 100-39-0 benzyl bromide 
• 4026-18-0 2-hydroxy-3-methylbutanoic acid 
• 17417-00-4 methyl 2-hydroxy-3-methylbutanoate 
• 110351-27-4 methyl 2-benzyloxy-3-methylbutanoate 
• 81927-55-1 O-benzyl 2,2,2-trichloroacetimidate 
• 84994-57-0 (R)-2-Methyl-1-((S)-2-phenyl-hexahydro-pyrrolo[1,2-c]imidazol-3-yl)-propan-1-ol 
• 24347-63-5 methyl (S)-2-hydroxy-3-methylbutanoate 
• 17407-55-5 (S)-2-Hydroxy-3-methylbutanoic acid 
• 72-18-4 L-valine 
• 110298-78-7 methyl (S)-2-(benzyloxy)-3-methylbutanoate 

Downstream Products

• 96925-01-8 2-(Benzyloxy)-3-methylbutanal 
• 185461-58-9 (2RS,4S)-N-(4-Benzyloxy-2,5-dimethyl-3-oxohexanoyl)leucine trichloroethyl ester 
• 1263469-87-9 (3α,5R,6β,22E,24S)-24-benzyloxy-6-methoxy-3,5-cyclocholest-22-ene 
• 57333-96-7 tacalcitol 
• 110840-40-9 (3S,4S)-4-Benzyloxy-5-methyl-1-phenyl-hex-1-yn-3-ol 
• 129919-83-1 (3S,4R,5S)-4-<<(benzyloxy)carbonyl>amino>-3-<(triisopropylsilyl)oxy>-5-methyl-heptanoic acid, (1S,2S,3R)-4-<(tert-butyldimethylsilyl)oxy>-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl ester 
• 130008-94-5 (3R,4R,5S)-4-<<(benzyloxy)carbonyl>amino>-3-<(triisopropylsilyl)oxy>-5-methyl-heptanoic acid, (1S,2S,3R)-4-<(tert-butyldimethylsilyl)oxy>-1-isopropyl-2-(methoxymethoxy)-3-methylbutyl ester 
• 126587-62-0 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3R)-4- 
• 126587-64-2 N-<1--L-leucyl>-L-prolyl>-3-(p-methoxyphenyl)-N-methyl-L-alanine, ester with (3S,4R,5S)-3-<(triisopropylsilyl)oxy>-4-<(2S,3R)-2-<(tert-butoxycarbonyl)amino>-3-hydroxybutyramido>-5-methylheptanoic acid, (1S,2S,3S)-1-isopropyl-2- 

Relevant articles and documents

Process Development of Tacalcitol

A highly convergent, gram-scale synthesis of vitamin D3 analogue tacalcitol 1 is disclosed, starting from L-valine and Inhoffen-Lythgoe diol. Key features of the synthesis include modified Julia olefination reaction of β-oxybenzothiazol-2-yl sulfone with C/D ring containing aldehyde to access decagrams of fully functionalized C/D ring synthon. The Horner-Wadsworth-Emmons (HWE) reaction between the C/D ring fragment and commercially available phosphonate completes the carbo-skeleton, which is elaborated into tacalcitol 1 in a gram-scale synthesis.

Process for Preparing Tacalcitol and Intermediate Therefor

The present invention relates to a process for preparing tacalcitol and an intermediate body used therefor. According to the preparation method of the present invention, tacalcitol can be effectively and economically prepared without a complex and long preparation process.COPYRIGHT KIPO 2018

Synthesis of derivatives of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnins

The syntheses of the two protected derivatives 7 and 16 of (2S,4S)-4-hydroxy-2,5-dimethyl-3-oxohexanoic acid, a constituent of the didemnin family of antineoplastic macrocyclic depsipeptides are described. The preparation of 7 was carried out by modificat