14-Oxa-2,7,12-triazahexadeca-4,9-dienoic acid, 2,7,12-tris[(4-fluorophenyl)sulfonyl]-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester, (4E,9E)-

Base Information

• Chemical Name: 14-Oxa-2,7,12-triazahexadeca-4,9-dienoic acid, 2,7,12-tris[(4-fluorophenyl)sulfonyl]-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester, (4E,9E)-
• CAS No.: 850334-72-4
• Molecular Formula: C36H42F3N3O10S3
• Molecular Weight: 829.937
• Mol file: 850334-72-4.mol

Synonyms:

Chemical Property of 14-Oxa-2,7,12-triazahexadeca-4,9-dienoic acid, 2,7,12-tris[(4-fluorophenyl)sulfonyl]-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester, (4E,9E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 14-Oxa-2,7,12-triazahexadeca-4,9-dienoic acid, 2,7,12-tris[(4-fluorophenyl)sulfonyl]-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester, (4E,9E)-

There total 3 articles about 14-Oxa-2,7,12-triazahexadeca-4,9-dienoic acid, 2,7,12-tris[(4-fluorophenyl)sulfonyl]-15,15-dimethyl-13-oxo-, 1,1-dimethylethyl ester, (4E,9E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-[(E)-4-bromo-2-butenyl]-N-(tert-butyloxycarbonyl)-(4-fluorophenyl)sulfonamide (850334-59-7) + 4-fluorophenylsulphonamide (402-46-0) → (E,E)-1,11-bis(tert-butyloxycarbonyl)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene (850334-72-4)

Guidance literature:

With potassium carbonate; In acetonitrile; for 18h; Heating;

DOI:10.1055/s-2004-834938

Reference yield: 90.0%

N-[(E)-4-chloro-2-buten-1-yl]-N-(tert-butoxycarbonyl)-(4-fluorophenyl)sulfonamide (918401-81-7) + 4-fluorophenylsulphonamide (402-46-0) → (E,E)-1,11-bis(tert-butyloxycarbonyl)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene (850334-72-4)

Guidance literature:

With potassium carbonate; In acetonitrile; for 7h; Heating;

DOI:10.1039/b608673j

Reference yield:

N-(tert-butyloxycarbonyl)-4-fluorobenzenesulfonamide (501682-72-0) → (E,E)-1,11-bis(tert-butyloxycarbonyl)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene (850334-72-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / potassium carbonate / acetonitrile / 16 h / Heating

2: 90 percent / potassium carbonate / acetonitrile / 7 h / Heating

With potassium carbonate; In acetonitrile;

DOI:10.1039/b608673j

upstream raw materials:

N-[(E)-4-bromo-2-butenyl]-N-(tert-butyloxycarbonyl)-(4-fluorophenyl)sulfonamide

4-fluorophenylsulphonamide

N-[(E)-4-chloro-2-buten-1-yl]-N-(tert-butoxycarbonyl)-(4-fluorophenyl)sulfonamide

N-(tert-butyloxycarbonyl)-4-fluorobenzenesulfonamide

Downstream raw materials:

(E,E)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazaundeca-3,8-diene

1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazacyclopentadecane

(E,E,E)-1,6,11-tris[(4-fluorophenyl)sulfonyl]-1,6,11-triazacyclopentadeca-3,8,13-triene