3-Pyridinecarbonyl chloride, 5-chloro- (9CI)

Base Information

• Chemical Name: 3-Pyridinecarbonyl chloride, 5-chloro- (9CI)
• CAS No.: 85320-79-2
• Molecular Formula: C6H3Cl2NO
• Molecular Weight: 176.002
• Mol file: 85320-79-2.mol

Synonyms:

Chemical Property of 3-Pyridinecarbonyl chloride, 5-chloro- (9CI)

Chemical Property:

• Boiling Point: 234.1±20.0 °C(Predicted)
• PKA: 0.34±0.20(Predicted)
• Density: 1.454±0.06 g/cm3(Predicted)

Purity/Quality:

99%min ^*data from raw suppliers

5-Chloronicotinoyl chloride 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Pyridinecarbonyl chloride, 5-chloro- (9CI)

There total 3 articles about 3-Pyridinecarbonyl chloride, 5-chloro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

nicotinic acid (59-67-6) + thionyl chloride (7719-09-7) → 5-chloro-nicotinoyl chloride (85320-79-2) + 5,6-dichloronicotinoyl chloride (54127-29-6)

Guidance literature:

Reference yield:

→ 5-chloro-nicotinoyl chloride (85320-79-2)

Guidance literature:

With thionyl chloride; Erhitzen des Reaktionsgemisches auf 130grad;

DOI:10.1021/ja01187a020

Reference yield:

6-Chloro-3-pyridinecarboxylic acid (5326-23-8) → 5-chloro-nicotinoyl chloride (85320-79-2)

Guidance literature:

With phosphorus pentachloride; trichlorophosphate;

DOI:10.1021/jm9708644

upstream raw materials:

6-Chloro-3-pyridinecarboxylic acid

nicotinic acid

thionyl chloride

Downstream raw materials:

5-carboxamido-3-chloropyridine

3-chloro-5-pyridinecarboxaldehyde

2-Chloro-5-hydroxymethylpyridine

Refernces