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2,3-Dichloropyridine-5-carbonyl chloride is a chemical compound characterized by the molecular formula C6H2Cl3NO. It is a reactive and highly toxic reagent utilized in organic synthesis for the preparation of a range of pharmaceutical and agrochemical products. 2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE serves as a crucial intermediate in the production of pesticides and agricultural chemicals, as well as in the manufacturing process of pharmaceuticals, dyes, and other organic compounds. Due to its toxic and corrosive properties, it requires careful handling and management.

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  • 54127-29-6 Structure
  • Basic information

    1. Product Name: 2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE
    2. Synonyms: BUTTPARK 154\50-12;2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE;5,6-DICHLOROPYRIDINE-3-CARBONYL CHLORIDE;5,6-Dichloronicotinoyl chloride;5,6-Dichloropyridine-3-carbonyl chloride, 5-(Chlorocarbonyl)-2,3-dichloropyridine;3-PYRIDINECARBONYL CHLORIDE, 5,6-DICHLORO-
    3. CAS NO:54127-29-6
    4. Molecular Formula: C6H2Cl3NO
    5. Molecular Weight: 210.45
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 54127-29-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 265.2 °C at 760 mmHg
    3. Flash Point: 114.2 °C
    4. Appearance: /
    5. Density: 1.582 g/cm3
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: 2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE(CAS DataBase Reference)
    10. NIST Chemistry Reference: 2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE(54127-29-6)
    11. EPA Substance Registry System: 2,3-DICHLOROPYRIDINE-5-CARBONYL CHLORIDE(54127-29-6)
  • Safety Data

    1. Hazard Codes: C
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 54127-29-6(Hazardous Substances Data)

54127-29-6 Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dichloropyridine-5-carbonyl chloride is used as a key intermediate for the synthesis of various pharmaceuticals. Its reactivity allows for the creation of new compounds with potential therapeutic applications, contributing to the development of novel drugs and treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2,3-dichloropyridine-5-carbonyl chloride is employed as a vital component in the production of pesticides and other agricultural chemicals. Its role in these processes helps to develop more effective and targeted pest control solutions, enhancing crop protection and yield.
Used in Dye Manufacturing:
2,3-Dichloropyridine-5-carbonyl chloride is used as a reactive intermediate in the synthesis of dyes. Its unique properties enable the creation of a variety of dyes with specific characteristics, catering to the needs of different industries that rely on coloring agents.
Used in Organic Synthesis:
Beyond its applications in specific industries, 2,3-dichloropyridine-5-carbonyl chloride is a versatile reagent in organic synthesis. It is used to produce a wide array of organic compounds for research, industrial processes, and commercial applications, highlighting its importance in the field of chemistry.

Check Digit Verification of cas no

The CAS Registry Mumber 54127-29-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,1,2 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 54127-29:
(7*5)+(6*4)+(5*1)+(4*2)+(3*7)+(2*2)+(1*9)=106
106 % 10 = 6
So 54127-29-6 is a valid CAS Registry Number.

54127-29-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloropyridine-3-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 5,6-Dichloronicotinoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54127-29-6 SDS

54127-29-6Relevant articles and documents

Rational design of a fluopyram hapten and preparation of bioconjugates and antibodies for immunoanalysis

Ceballos-Alcantarilla,Agulló,Abad-Fuentes,Abad-Somovilla,Mercader

, p. 51337 - 51341 (2015/06/25)

A fluopyram hapten was designed in which insignificant electronic and structural modifications were foreseen and all potentially interacting chemical moieties were maintained. This hapten was prepared by total synthesis and three immunologically active bi

Heterocyclic compounds

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Page/Page column 87-88, (2015/11/09)

The invention relates to compounds of Formula I: wherein Ar1, Ar2, Ar3, L1, L2, Y, Z and v are defined in the specification, and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of Formula I or a pharmaceutically acceptable derivative thereof.

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket

Hong, Fang-Tsao,Norman, Mark H.,Ashton, Kate S.,Bartberger, Michael D.,Chen, Jie,Chmait, Samer,Cupples, Rod,Fotsch, Christopher,Jordan, Steven R.,Lloyd, David J.,Sivits, Glenn,Tadesse, Seifu,Hale, Clarence,St. Jean, David J.

, p. 5949 - 5964 (2014/08/18)

Structure-activity relationship investigations conducted at the 5-position of the N-pyridine ring of a series of N-arylsulfonyl-N′-2-pyridinyl- piperazines led to the identification of a novel bis-pyridinyl piperazine sulfonamide (51) that was a potent disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) interaction. Analysis of the X-ray cocrystal of compound 51 bound to hGKRP revealed that the 3-pyridine ring moiety occupied a previously unexplored binding pocket within the protein. Key features of this new binding mode included forming favorable contacts with the top face of the Ala27-Val28-Pro29 ("shelf region") as well as an edge-to-face interaction with the Tyr24 side chain. Compound 51 was potent in both biochemical and cellular assays (IC50 = 0.005 μM and EC 50 = 0.205 μM, respectively) and exhibited acceptable pharmacokinetic properties for in vivo evaluation. When administered to db/db mice (100 mg/kg, po), compound 51 demonstrated a robust pharmacodynamic effect and significantly reduced blood glucose levels up to 6 h postdose.

N-(HETEROARYL)-SULFONAMIDE DERIVATIVES USEFUL AS S100-INHIBITORS

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Page/Page column 100, (2014/12/12)

A compound of formula (I), or a pharmaceutically acceptable salt thereof and a pharmaceutical composition comprising the compound. The compound is an inhibitor of interactions between S100A9 and interaction partners such as RAGE, TLR4 and EMMPRIN and as such is useful in the treatment of disorders such as cancer, autoimmune disorders, inflammatory disorders and neurodegenerative disorders.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Lahm, George P.,Cordova, Daniel,Barry, James D.,Pahutski, Thomas F.,Smith, Ben K.,Long, Jeffrey K.,Benner, Eric A.,Holyoke, Caleb W.,Joraski, Kathleen,Xu, Ming,Schroeder, Mark E.,Wagerle, Ty,Mahaffey, Michael J.,Smith, Rejane M.,Tong, My-Hahn

, p. 3001 - 3006 (2013/06/26)

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

Substituted-nicotinyl thiourea derivatives bearing pyrimidine moiety: Synthesis and biological evaluation

Ke, Shaoyong,Cao, Xiufang

experimental part, p. 627 - 633 (2012/04/23)

A series of substituted-nicotinyl thiourea derivatives containing pyrimidine ring were synthesized in good to excellent yield using PEG-400 as solid-liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1H NMR and elemental analysis. The preliminary biological tests show that some of the target compounds present good inhibitory activities against the root and stalk of dicotyledon plants and are safe for monocotyledon plants.

MONOCYCLIC COMPOUNDS AND THEIR USE AS TRPV1 LIGANDS

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Page/Page column 95, (2010/06/11)

The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.

HETEROCYCLIC TRPV1 RECEPTOR LIGANDS

-

Page/Page column 169-170, (2010/06/16)

The invention relates to compounds of formulae I(a)-I(d): and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formulae I(a)-I(d) or a pharmaceutically acceptable derivative thereof.

BICYCLOHETEROARYL COMPOUNDS AND THEIR USE AS TRPV1 LIGANDS

-

Page/Page column 123, (2010/06/14)

The invention relates to compounds of formula I and pharmaceutically acceptable derivatives thereof, compositions comprising an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, UI, an ulcer, IBD and IBS, comprising administering to an animal in need thereof an effective amount of a compound of formula I or a pharmaceutically acceptable derivative thereof.

HETEROARYLOXY QUINAZOLINE DERIVATIVE

-

Page/Page column 72, (2010/09/05)

Disclosed are compounds of the following formula and their pharmaceutically-acceptable salts, which have an effect of glucokinase activation and are useful in the field of medicines for treatment for diabetes, obesity, etc. (wherein ring A represents a pyrazolyl group optionally having a lower alkyl group, etc.; ring B represents a heteroaryl group; R represents a lower alkyl group, etc.; R1 represents a group of a formula: (wherein R11 and R12 each independently represent a hydrogen atom, etc.; m indicates an integer of from 2 to 6), etc.; R2 represents a lower alkyl group, etc.; r indicates an integer of from 0 to 3; k indicates an integer of from 0 to 4).

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