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54127-29-6

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54127-29-6 Usage

General Description

2,3-Dichloropyridine-5-carbonyl chloride is a chemical compound with the molecular formula C6H2Cl3NO. It is a reactive and highly toxic compound that is used in organic synthesis as a reagent for the preparation of various pharmaceutical and agrochemical products. It is an important intermediate in the production of pesticides and other agricultural chemicals. It is also used in the manufacture of pharmaceuticals, dyes, and other organic compounds. However, it should be handled with caution due to its toxic and corrosive nature.

Check Digit Verification of cas no

The CAS Registry Mumber 54127-29-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,4,1,2 and 7 respectively; the second part has 2 digits, 2 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 54127-29:
(7*5)+(6*4)+(5*1)+(4*2)+(3*7)+(2*2)+(1*9)=106
106 % 10 = 6
So 54127-29-6 is a valid CAS Registry Number.

54127-29-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 5,6-dichloropyridine-3-carbonyl chloride

1.2 Other means of identification

Product number -
Other names 5,6-Dichloronicotinoyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:54127-29-6 SDS

54127-29-6Downstream Products

54127-29-6Relevant articles and documents

Rational design of a fluopyram hapten and preparation of bioconjugates and antibodies for immunoanalysis

Ceballos-Alcantarilla,Agulló,Abad-Fuentes,Abad-Somovilla,Mercader

, p. 51337 - 51341 (2015/06/25)

A fluopyram hapten was designed in which insignificant electronic and structural modifications were foreseen and all potentially interacting chemical moieties were maintained. This hapten was prepared by total synthesis and three immunologically active bi

Small molecule disruptors of the glucokinase-glucokinase regulatory protein interaction: 4. Exploration of a novel binding pocket

Hong, Fang-Tsao,Norman, Mark H.,Ashton, Kate S.,Bartberger, Michael D.,Chen, Jie,Chmait, Samer,Cupples, Rod,Fotsch, Christopher,Jordan, Steven R.,Lloyd, David J.,Sivits, Glenn,Tadesse, Seifu,Hale, Clarence,St. Jean, David J.

, p. 5949 - 5964 (2014/08/18)

Structure-activity relationship investigations conducted at the 5-position of the N-pyridine ring of a series of N-arylsulfonyl-N′-2-pyridinyl- piperazines led to the identification of a novel bis-pyridinyl piperazine sulfonamide (51) that was a potent disruptor of the glucokinase-glucokinase regulatory protein (GK-GKRP) interaction. Analysis of the X-ray cocrystal of compound 51 bound to hGKRP revealed that the 3-pyridine ring moiety occupied a previously unexplored binding pocket within the protein. Key features of this new binding mode included forming favorable contacts with the top face of the Ala27-Val28-Pro29 ("shelf region") as well as an edge-to-face interaction with the Tyr24 side chain. Compound 51 was potent in both biochemical and cellular assays (IC50 = 0.005 μM and EC 50 = 0.205 μM, respectively) and exhibited acceptable pharmacokinetic properties for in vivo evaluation. When administered to db/db mice (100 mg/kg, po), compound 51 demonstrated a robust pharmacodynamic effect and significantly reduced blood glucose levels up to 6 h postdose.

4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel

Lahm, George P.,Cordova, Daniel,Barry, James D.,Pahutski, Thomas F.,Smith, Ben K.,Long, Jeffrey K.,Benner, Eric A.,Holyoke, Caleb W.,Joraski, Kathleen,Xu, Ming,Schroeder, Mark E.,Wagerle, Ty,Mahaffey, Michael J.,Smith, Rejane M.,Tong, My-Hahn

, p. 3001 - 3006 (2013/06/26)

Isoxazoline insecticides have been shown to be potent blockers of insect GABA receptors with excellent activity on a broad pest range, including Lepidoptera and Hemiptera. Herein we report on the synthesis, biological activity and mode-of-action for a class of 4-heterocyclic aryl isoxazoline insecticides.

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