N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide

Base Information

Chemical Name:N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide
CAS No.:85370-85-0
Molecular Formula:C15H25NO2Si
Molecular Weight:279.454
Hs Code.:
DSSTox Substance ID:DTXSID20579506
Wikidata:Q82470038

Synonyms:85370-85-0;N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide;DTXSID20579506

Suppliers and Price of N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide

Chemical Property:

Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:279.165455575
Heavy Atom Count:19
Complexity:297

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN(CC)C(=O)C1=C(C(=CC=C1)OC)[Si](C)(C)C

Technology Process of N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide

There total 2 articles about N,N-Diethyl-3-methoxy-2-(trimethylsilyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 75-77-4
chloro-trimethyl-silane

: 62924-93-0
N,N-diethyl-3-methoxybenzamide

: 85370-85-0
N,N-diethyl-3-methoxy-2-(trimethylsilyl)benzamide

Guidance literature:: N,N-diethyl-3-methoxybenzamide; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

chloro-trimethyl-silane; In tetrahydrofuran; hexane; at -78 - 22 ℃; for 18h; Further stages.;
DOI:10.1016/j.bmcl.2007.04.018

Reference yield:

: 586-38-9
3-Methoxybenzoic acid

: 85370-85-0
N,N-diethyl-3-methoxy-2-(trimethylsilyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 89 percent / thionyl chloride

2.1: sec-butyllithium; TMEDA / hexane; tetrahydrofuran / 1 h / -78 °C

2.2: 90 percent / hexane; tetrahydrofuran / 18 h / -78 - 22 °C

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; hexane;
DOI:10.1016/j.bmcl.2007.04.018