Benzoic acid, 4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6 -(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester

Base Information

Chemical Name:Benzoic acid, 4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6 -(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester
CAS No.:859877-17-1
Molecular Formula:C25H18BrF6N3O3
Molecular Weight:602.331
Hs Code.:

Benzoic acid,
4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6
-(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester

Synonyms:

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Chemical Property of Benzoic acid, 4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6 -(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester

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Technology Process of Benzoic acid, 4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6 -(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester

There total 6 articles about Benzoic acid, 4-[[4-bromo-2,3-dihydro-3-methyl-2-[[4-(trifluoromethoxy)phenyl]imino]-6 -(trifluoromethyl)-1H-benzimidazol-1-yl]methyl]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859877-16-0
7-bromo-1-methyl-N-[4-(trifluoromethoxy)phenyl]-5-(trifluoromethyl)-1H-benzimidazol-2-amine

: 2417-72-3
Methyl 4-(bromomethyl)benzoate

: C₂₅H₁₈BrF₆N₃O₃

: 859877-17-1
methyl 4-[(4-bromo-6-trifluoromethyl-3-methyl-2-{[4-(trifluoromethoxy)-phenyl]imino}-2,3-dihydro-1H-benzimidazol-1-yl)methyl]benzoate

Guidance literature:: 7-bromo-1-methyl-N-[4-(trifluoromethoxy)phenyl]-5-(trifluoromethyl)-1H-benzimidazol-2-amine; With sodium hydride; In DMF (N,N-dimethyl-formamide); for 0.166667h;

Methyl 4-(bromomethyl)benzoate; In DMF (N,N-dimethyl-formamide); at 20 ℃; for 12h;

Reference yield:

: 859877-14-8
(2-bromo-6-nitro-4-trifluoromethyl-phenyl)-methyl-amine

: 859877-17-1
methyl 4-[(4-bromo-6-trifluoromethyl-3-methyl-2-{[4-(trifluoromethoxy)-phenyl]imino}-2,3-dihydro-1H-benzimidazol-1-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tin(II) chloride dihdyrate / water; N,N-dimethyl-formamide / 40 °C

2.1: dichloromethane / 40 °C

2.2: 20 °C

3.1: acetonitrile / 110 °C

With tin(II) chloride dihdyrate; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.085

Reference yield:

: 113170-71-1
2-bromo-6-nitro-4-(trifluoromethyl)aniline

: 859877-17-1
methyl 4-[(4-bromo-6-trifluoromethyl-3-methyl-2-{[4-(trifluoromethoxy)-phenyl]imino}-2,3-dihydro-1H-benzimidazol-1-yl)methyl]benzoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 20 °C

2.1: tin(II) chloride dihdyrate / water; N,N-dimethyl-formamide / 40 °C

3.1: dichloromethane / 40 °C

3.2: 20 °C

4.1: acetonitrile / 110 °C

With tin(II) chloride dihdyrate; sodium hydride; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.09.085