Benzeneethanol, b-(phenylethynyl)-

Base Information

• Chemical Name: Benzeneethanol, b-(phenylethynyl)-
• CAS No.: 86100-15-4
• Molecular Formula: C16H14O
• Molecular Weight: 222.287
• Mol file: 86100-15-4.mol

Synonyms:2,4-Diphenyl-but-3-in-1-ol;(+-)-4-Hydroxy-1.3-diphenyl-butin-(1);2,4-diphenylbut-3-yn-1-ol;2,4-Diphenyl-but-3-yn-1-ol;2,4-diphenyl-3-butyn-1-ol;

Chemical Property of Benzeneethanol, b-(phenylethynyl)-

Chemical Property:

• Melting Point: 51 °C
• Boiling Point: 145 - 150 °C (0.2 mmHg)
• PSA: 20.23000
• Density: 1.12±0.1 g/cm3(Predicted)
• LogP: 2.81420

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzeneethanol, b-(phenylethynyl)-

There total 6 articles about Benzeneethanol, b-(phenylethynyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 1-Phenylethynyl-1H-1λ3-benzo[d][1,2]iodoxol-3-one → 2,4-Diphenyl-3-butin-1-ol (86100-15-4)

Guidance literature:

With ammonium peroxydisulfate; water; In [D₃]acetonitrile; at 90 ℃; for 1h; Reagent/catalyst;

DOI:10.1021/acs.orglett.8b02954

Reference yield: 68.0%

triphenylborane (960-71-4) → 2,4-Diphenyl-3-butin-1-ol (86100-15-4)

Guidance literature:

With sodium hydroxide; n-butyllithium; dihydrogen peroxide; boron trichloride; In tetrahydrofuran; hexane; 1.) -78 deg C to r.t; 2.) -78 deg C to r.t.; 3.) 40 deg C, 1 h;

DOI:10.1016/0040-4039(95)01756-8

Reference yield: 45.0%

(R)-Styrene oxide (20780-53-4) + lithium phenylacetylide (4440-01-1) → (R)-1,4-diphenylbut-3-yn-1-ol + 2,4-Diphenyl-3-butin-1-ol (86100-15-4)

Guidance literature:

With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃; for 0.166667h;

DOI:10.1246/cl.2006.768

upstream raw materials:

styrene oxide

phenylacetylene

lithium phenylacetylide

triphenylborane

Downstream raw materials:

2,4-diphenyl-1-butanol

racem-2,4-Diphenyl-butyltosylat

(E)-2,4-diphenylbut-3-en-1-ol

(E)-4-phenyl-3-(1-phenylethylidene)dihydro-2(3H)-furanone