1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol

Base Information

Chemical Name:1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol
CAS No.:86111-04-8
Molecular Formula:C16H15NO2
Molecular Weight:253.301
Hs Code.:
ChEMBL ID:CHEMBL33485
DSSTox Substance ID:DTXSID20539842
Nikkaji Number:J601.852A
Wikidata:Q82415653

Synonyms:1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol;86111-04-8;CHEMBL33485;DTXSID20539842

Suppliers and Price of 1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:253.110278721
Heavy Atom Count:19
Complexity:301

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1C2=C(C=C(C=C2)O)C=C1C3=CC=C(C=C3)O

Technology Process of 1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol

There total 4 articles about 1-Ethyl-2-(4-hydroxyphenyl)-1H-indol-5-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91444-30-3
1-Ethyl-5-methoxy-2-(4-methoxyphenyl)-indol

: 86111-04-8
1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol

Guidance literature:: With boron tribromide; In dichloromethane; at -60 - 20 ℃;
DOI:10.1021/jm00377a011

Reference yield:

: 5883-83-0
5-methoxy-2-(4-methoxyphenyl)-1H-indole

: 86111-04-8
1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) Na/liquid NH₃ / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

2: BBr₃ / CH₂Cl₂ / -60 - 20 °C

With ammonia; sodium; boron tribromide; In dichloromethane;
DOI:10.1021/jm00377a011

Reference yield:

: 104-94-9
4-methoxy-aniline

: 86111-04-8
1-Ethyl-5-hydroxy-2-(4-hydroxyphenyl)-indol

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethylaniline / 170 °C

2: 1.) Na/liquid NH₃ / 1.) THF, -70 deg C, 30 min, 2.) THF, -70 deg C, 30 min

3: BBr₃ / CH₂Cl₂ / -60 - 20 °C

With ammonia; sodium; boron tribromide; N,N-dimethyl-aniline; In dichloromethane;
DOI:10.1021/jm00377a011