N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride

Base Information

Chemical Name:N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride
CAS No.:72412-44-3
Molecular Formula:C₁₃H₂₀N₄O₂*ClH
Molecular Weight:300.788
Hs Code.:
DSSTox Substance ID:DTXSID90993215

Synonyms:N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride;5-Pyrimidinecarboxamide, N-((1-ethyl-2-pyrrolidinyl)methyl)-4-methoxy-, monohydrochloride;72412-44-3;DTXSID90993215;LS-134818;N-[(1-Ethylpyrrolidin-2-yl)methyl]-4-methoxypyrimidine-5-carboximidic acid--hydrogen chloride (1/1)

Suppliers and Price of N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride

Chemical Property:

Vapor Pressure:4.16E-08mmHg at 25°C
Boiling Point:444.8°Cat760mmHg
Flash Point:222.8°C
Density:g/cm³
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:300.1353036
Heavy Atom Count:20
Complexity:300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCN1CCCC1CNC(=O)C2=CN=CN=C2OC.Cl

Technology Process of N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride

There total 3 articles about N-((1-Ethyl-2-pyrrolidinyl)methyl)-4-methoxy-5-pyrimidinecarboxamide monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 84332-00-3
methyl 4-methoxypyrimidine-5-carboxylate

: 72412-44-3
4-Methoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH / methanol; H₂O / 1 h / 65 °C

2: 1.) triethylamine, ethylchloroformate / 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 41103-17-7
ethyl 4-chloropyrimidine-5-carboxylate

: 72412-44-3
4-Methoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 64 percent / sodium / Ambient temperature

2: NaOH / methanol; H₂O / 1 h / 65 °C

3: 1.) triethylamine, ethylchloroformate / 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight

With sodium hydroxide; sodium; chloroformic acid ethyl ester; triethylamine; In methanol; water;

Reference yield:

: 26116-12-1
1-ethyl-2-pyrrolidinemethanamine

: 72411-89-3
4-methoxy-5-pyrimidinyl carboxylic acid

: 72412-44-3
4-Methoxy-pyrimidine-5-carboxylic acid (1-ethyl-pyrrolidin-2-ylmethyl)-amide; hydrochloride

Guidance literature:: With chloroformic acid ethyl ester; triethylamine; Yield given. Multistep reaction; 1.) THF, 0 deg C, 30 min, 2.) room temp. overnight;