1-(4-FLUORO-BENZYL)-PYRROLIDINE-2,5-DIONE

Base Information

• Chemical Name: 1-(4-FLUORO-BENZYL)-PYRROLIDINE-2,5-DIONE
• CAS No.: 86386-65-4
• Molecular Formula: C11H10FNO2
• Molecular Weight: 207.204
• Mol file: 86386-65-4.mol

Synonyms:N-4-fluorobenzyl-succinimide;

Chemical Property of 1-(4-FLUORO-BENZYL)-PYRROLIDINE-2,5-DIONE

Chemical Property:

• PSA: 37.38000
• LogP: 1.41260
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

1-(4-Fluorobenzyl)pyrrolidine-2,5-dione 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(4-FLUORO-BENZYL)-PYRROLIDINE-2,5-DIONE

There total 6 articles about 1-(4-FLUORO-BENZYL)-PYRROLIDINE-2,5-DIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

Succinimide (123-56-8,89963-74-6) + 4-Fluorobenzyl bromide (459-46-1) → 1-[(4-fluorophenyl)methyl]-2,5-pyrrolidinedione (86386-65-4)

Guidance literature:

Succinimide; With potassium carbonate; In acetone; for 0.0833333h;

4-Fluorobenzyl bromide; In acetone; Heating / reflux;

Reference yield: 91.0%

succinic acid anhydride (108-30-5) + para-fluorobenzylamine (140-75-0) → 1-[(4-fluorophenyl)methyl]-2,5-pyrrolidinedione (86386-65-4)

Guidance literature:

With dmap; acetic acid; for 24h; Heating;

DOI:10.1021/jm049559q

Reference yield: 72.0%

Butane-1,4-diol (110-63-4) + para-fluorobenzylamine (140-75-0) → 1-[(4-fluorophenyl)methyl]-2,5-pyrrolidinedione (86386-65-4)

Guidance literature:

With C₂₁H₃₅BrMnN₂O₂P; potassium hydride; In toluene; for 40h; Reflux; Inert atmosphere;

upstream raw materials:

succinic acid anhydride

para-fluorobenzylamine

Succinimide

4-Fluorobenzyl bromide

Downstream raw materials:

carbonic acid ethyl ester 7-(4-fluoro-benzyl)-3,5-dimethoxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-9-yl ester

carbonic acid ethyl ester 7-(4-fluoro-benzyl)-5-hydroxy-3-methoxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-9-yl ester

9-benzhydryloxy-7-(4-fluoro-benzyl)-3,5-dimethoxy-pyrrolo[3,4-g]quinoline-6,8-dione

carbonic acid 5-ethoxycarbonyloxy-7-(4-fluoro-benzyl)-3-methoxy-6,8-dioxo-7,8-dihydro-6H-pyrrolo[3,4-g]quinolin-9-yl ester ethyl ester

Refernces

• 1、 -. "MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS". Paragraph 00394. . Retrieved 2017/09/05.
• 2、 Alanazi, Amer M.,El-Azab, Adel S.,Al-Suwaidan, Ibrahim A.,Eltahir, Kamal Eldin H.,Asiri, Yousif A.,Abdel-Aziz, Naglaa I.,Abdel-Aziz, Alaa A.-M.. "Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities". . p. 115 - 123. Retrieved 2015/02/19.