Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester

Base Information

Chemical Name:Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester
CAS No.:86536-92-7
Molecular Formula:C18H29NO5S
Molecular Weight:371.498
Hs Code.:

Synonyms:6-(tert-butoxycarbonylamino)hexyl 4-methylbenzenesulfonate;6-(p-toluenesulfonyloxy)-N-(tert-butoxycarbonyl)aminohexane;6-((tert-butoxycarbonyl)amino)hexyl p-toluenesulfonate;6-(p-toluenesulfonyloxy)-N-(tert-butoxycarbonyl)hexylamine;6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate;Toluene-4-sulfonic acid 6-tert-butoxycarbonylamino-hexyl ester;N-tert-butyloxycarbonyl-6-aminohexyl-4-toluenesulfonate;

Suppliers and Price of Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 5 raw suppliers

Chemical Property of Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester

Chemical Property:

PSA：90.08000
LogP:5.25710

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description 6-((tert-Butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate is a six carbon linker containing a tosyl group and Boc-protected amine group. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The Boc group can be deprotected under mild acidic conditions to form a free amine.

Technology Process of Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester

There total 8 articles about Carbamic acid, [6-[[(4-methylphenyl)sulfonyl]oxy]hexyl]-, 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 144183-31-3
N-(8-hydroxyoctyl)carbamic acid tert-butyl ester

: 98-59-9
p-toluenesulfonyl chloride

: 86536-92-7
6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h;

Reference yield: 94.7%

: 75937-12-1
6-(Boc-amino)-1-hexanol

: 98-59-9
p-toluenesulfonyl chloride

: 86536-92-7
6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; Reagent/catalyst; Temperature;

Reference yield:

: 4048-33-3
6-amino-1-hexanol

: 86536-92-7
6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 91 percent / Et₃N / dimethylsulfoxide

2: 40 percent / pyridine / 0 °C

With triethylamine; In pyridine; dimethyl sulfoxide;
DOI:10.1039/c39830000162