tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate

Base Information

• Chemical Name: tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate
• CAS No.: 1419639-24-9
• Molecular Formula: C₃₁H₄₅N₅O₄
• Molecular Weight: 551.729
• Mol file: 1419639-24-9.mol

Synonyms:tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate

Chemical Property of tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate

There total 3 articles about tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide (868072-17-7) + 6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate (86536-92-7) → tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate (1419639-24-9)

Guidance literature:

With sodium hydroxide; In dimethyl sulfoxide; at 50 ℃;

DOI:10.1002/mrc.3919

Reference yield:

6-(Boc-amino)-1-hexanol (75937-12-1) → tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate (1419639-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; dmap / dichloromethane / 20 °C / Inert atmosphere

2: sodium hydroxide / dimethyl sulfoxide / 50 °C

With dmap; triethylamine; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/mrc.3919

Reference yield:

2-[2-(4'-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide (386297-97-8) → tert-butyl (6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)carbamate (1419639-24-9)

Guidance literature:

Multi-step reaction with 2 steps

1: boron tribromide / dichloromethane / 5 h / -60 - -20 °C

2: sodium hydroxide / dimethyl sulfoxide / 50 °C

With boron tribromide; sodium hydroxide; In dichloromethane; dimethyl sulfoxide;

DOI:10.1002/mrc.3919

upstream raw materials:

6-(Boc-amino)-1-hexanol

2-[2-(4'-methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

2-[2-(4'-hydroxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl]-N,N-diethylacetamide

6-((tert-butoxycarbonyl)amino)hexyl 4-methylbenzenesulfonate

Downstream raw materials:

2-(2-(4-((6-aminohexyl)oxy)phenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl)-N,N-diethylacetamide

C₅₄H₈₇N₉O₉

2,2',2''-(10-(2-((6-(4-(3-(2-(diethylamino)-2-oxoethyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexyl)amino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid

gadolinium(III) 2,2',2''-(10-(2-(6-(4-(3-(2-(diethylamino)-2-oxoethyl)5,7-dimethylpyrazolo[1,5-a]pyrimidin-2-yl)phenoxy)hexylamino)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetate