Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate

Base Information

Chemical Name:Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate
CAS No.:86537-54-4
Molecular Formula:C13H16O4S
Molecular Weight:268.334
Hs Code.:
DSSTox Substance ID:DTXSID20568399
Wikidata:Q82454639

Synonyms:86537-54-4;Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate;DTXSID20568399

Suppliers and Price of Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate

Chemical Property:

XLogP3:2.1
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:5
Exact Mass:268.07693016
Heavy Atom Count:18
Complexity:397

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1(CCC1)S(=O)(=O)C2=CC=CC=C2

Technology Process of Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate

There total 4 articles about Ethyl 1-(benzenesulfonyl)cyclobutane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 541-41-3
chloroformic acid ethyl ester

: 78710-80-2
(cyclobutylsulfonyl)benzene

: 86537-54-4
1-Benzenesulfonyl-cyclobutanecarboxylic acid ethyl ester

Guidance literature:: DOI:10.1016/S0040-4039(00)85802-5

Reference yield: 33.0%

: 7605-30-3
ethyl 2-phenylsulfonylacetate

: 109-64-8
1,3-dibromo-propane

: 86537-54-4
1-Benzenesulfonyl-cyclobutanecarboxylic acid ethyl ester

Guidance literature:: With tetrabutylammomium bromide; potassium carbonate; In toluene; for 12h; Heating;

Reference yield:

: 80989-84-0
1-(phenylsulfonyl)bicyclo[1.1.0]butane

: 86537-54-4
1-Benzenesulfonyl-cyclobutanecarboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 94 percent / LiAlH₄ / tetrahydrofuran / 0 °C

2: 1.) BuLi / 1.) THF, -15 deg C, 10 min, 2.) THF, 10 min

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1021/jo00216a028