2(1H)-Isoquinolinepropanoic acid, 3,4-dihydro-6-[3-(methylamino)-2-nitrophenoxy]-1-oxo-, ethyl ester

Base Information

Chemical Name:2(1H)-Isoquinolinepropanoic acid, 3,4-dihydro-6-[3-(methylamino)-2-nitrophenoxy]-1-oxo-, ethyl ester
CAS No.:866082-81-7
Molecular Formula:C21H23N3O6
Molecular Weight:413.43
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(1H)-Isoquinolinepropanoic acid, 3,4-dihydro-6-[3-(methylamino)-2-nitrophenoxy]-1-oxo-, ethyl ester

Chemical Property:

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Technology Process of 2(1H)-Isoquinolinepropanoic acid, 3,4-dihydro-6-[3-(methylamino)-2-nitrophenoxy]-1-oxo-, ethyl ester

There total 6 articles about 2(1H)-Isoquinolinepropanoic acid, 3,4-dihydro-6-[3-(methylamino)-2-nitrophenoxy]-1-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 866082-80-6
C₂₀H₁₉FN₂O₆

: 74-89-5
methylamine

: 866082-81-7
C₂₁H₂₃N₃O₆

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); at 25 ℃; for 18h;

Reference yield:

: 866082-79-3
C₁₄H₁₇NO₄

: 866082-81-7
C₂₁H₂₃N₃O₆

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 80 °C

2: tetrahydrofuran; N,N-dimethyl-formamide / 23 °C

With caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.074

Reference yield:

: 866082-78-2
C₂₁H₂₃NO₄

: 866082-81-7
C₂₁H₂₃N₃O₆

Guidance literature:: Multi-step reaction with 3 steps

1: 10% palladium on activated carbon; hydrogen / ethanol / 760.05 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 80 °C

3: tetrahydrofuran; N,N-dimethyl-formamide / 23 °C

With 10% palladium on activated carbon; hydrogen; caesium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2008.11.074