6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine

Base Information

Chemical Name:6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine
CAS No.:86627-00-1
Molecular Formula:C13H14ClN3O2S
Molecular Weight:311.792
Hs Code.:
DSSTox Substance ID:DTXSID80540050
Wikidata:Q82415919

Synonyms:86627-00-1;6-Chloro-N-(2,3-dimethylphenyl)-2-(methylsulfonyl)pyrimidin-4-amine;SCHEMBL10997171;DTXSID80540050;6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine

Suppliers and Price of 6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:311.0495256
Heavy Atom Count:20
Complexity:426

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)S(=O)(=O)C)Cl)C

Technology Process of 6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine

There total 6 articles about 6-Chloro-N-(2,3-dimethylphenyl)-2-(methanesulfonyl)pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 86626-95-1
6-chloro-N-(2,3-dimethylphenyl)-2-(methylsulfanyl)pyrimidin-4-amine

: 86627-00-1
6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine

Guidance literature:: With sodium tungstate (VI) dihydrate; dihydrogen peroxide; acetic acid; at 20 ℃; for 24h;
DOI:10.1021/acs.jmedchem.8b01848

Reference yield:

: Na₂ WO₄

: 7722-84-1
dihydrogen peroxide

: 86626-95-1
6-chloro-N-(2,3-dimethylphenyl)-2-(methylsulfanyl)pyrimidin-4-amine

: 86627-00-1
6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine

Guidance literature:: In water; acetic acid;

Reference yield:

: 6299-25-8
4,6-Dichloro-2-(methylthio)pyrimidine

: 86627-00-1
6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / Na₂CO₃ / acetonitrile / 18 h / Heating

2: 80 percent / 30percent aq. H₂O₂, Na₂WO₄ / acetic acid / 16 h / 20 °C

With sodium tungstate; dihydrogen peroxide; sodium carbonate; In acetic acid; acetonitrile;
DOI:10.1021/jm00378a016