Lodinixil

Base Information

Chemical Name:Lodinixil
CAS No.:86627-50-1
Molecular Formula:C14H17ClN4
Molecular Weight:276.76
Hs Code.:2933599090
UNII:P2I071P32B
DSSTox Substance ID:DTXSID60235715
Nikkaji Number:J25.824E
Wikidata:Q27286036
NCI Thesaurus Code:C66024
ChEMBL ID:CHEMBL297407
Mol file:86627-50-1.mol

Synonyms:Lodinixil;86627-50-1;Lodinixil [INN];pyrimidinediamine;UNII-P2I071P32B;P2I071P32B;4-Chloro-2-(dimethylamino)-6-(2,3-xylidino)pyrimidine;6-chloro-N4-(2,3-dimethylphenyl)-N2,N2-dimethylpyrimidine-2,4-diamine;CHEMBL297407;SCHEMBL3238255;DTXSID60235715;6-chloro-4-N-(2,3-dimethylphenyl)-2-N,2-N-dimethylpyrimidine-2,4-diamine;AKOS040752648;Q27286036;4-Chloro-2-(dimethylamino)-6-(2,3-xylidino)pyrimidine.

Suppliers and Price of Lodinixil

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
LODINIXIL 95.00%
5MG
$ 496.03

Total 6 raw suppliers

Chemical Property of Lodinixil

Chemical Property:

Vapor Pressure:2.02E-07mmHg at 25°C
Boiling Point:424.7°C at 760 mmHg
Flash Point:210.7°C
PSA：44.28000
Density:1.233g/cm³
LogP:2.97830
XLogP3:4.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:276.1141743
Heavy Atom Count:19
Complexity:287

Purity/Quality:

95% ^*data from raw suppliers

LODINIXIL 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(C(=CC=C1)NC2=CC(=NC(=N2)N(C)C)Cl)C

Technology Process of Lodinixil

There total 4 articles about Lodinixil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 86627-00-1
6-chloro-N-(2,3-dimethylphenyl)-2-methylsulfonylpyrimidin-4-amine

: 124-40-3
dimethyl amine

: 86627-50-1
4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine

Guidance literature:: With triethylamine; In water; benzene; at 80 ℃; for 18h;
DOI:10.1021/jm00378a016

Reference yield: 67.8%

: 86627-10-3
2,4-dichloro-6-<(2,3-dimethylphenyl)amino>pyrimidine

: 124-40-3
dimethyl amine

: 86627-50-1
4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine

Guidance literature:: With sodium carbonate; In ethanol; water; for 18h; Heating;
DOI:10.1021/jm00378a016

Reference yield:

: 87-59-2
2,3-Dimethylaniline

: 86627-50-1
4-chloro-2-(dimethylamino)-6-[(2,3-dimethylphenyl)amino]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: 75.1 percent / Na₂CO₃ / ethanol / 1.) RT, 20 h, 2.) reflux, 7 h

2: 67.8 percent / Na₂CO₃ / ethanol; H₂O / 18 h / Heating

With sodium carbonate; In ethanol; water;
DOI:10.1021/jm00378a016