1-(5-Bromo-7-azaindole)ethanone

Base Information

• Chemical Name: 1-(5-Bromo-7-azaindole)ethanone
• CAS No.: 866545-96-2
• Molecular Formula: C9H7BrN2O
• Molecular Weight: 239.071
• Hs Code.: 2933990090
• Mol file: 866545-96-2.mol

Synonyms:3-Acetyl-5-bromo-7-azaindole;ETHANONE,1-(5-BROMO-1H-PYRROLO[2,3-B]PYRIDIN-3-YL);1-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-yl)-ethanone;1-(5-BROMO-7-AZAINDOLE)ETHANONE;1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanone;

Chemical Property of 1-(5-Bromo-7-azaindole)ethanone

Chemical Property:

• PKA: 11.29±0.40(Predicted)
• PSA: 45.75000
• Density: 1.674±0.06 g/cm3(Predicted)
• LogP: 2.52800
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

1-{5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-one 97.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(5-Bromo-7-azaindole)ethanone

There total 2 articles about 1-(5-Bromo-7-azaindole)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetyl chloride (75-36-5) + 5-bromo-1H-pyrrolo[2,3-b]pyridine (183208-35-7) → 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (866545-96-2)

Guidance literature:

With aluminum (III) chloride; In dichloromethane; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2010.10.108

Reference yield: 91.0%

acetyl chloride (75-36-5) → 1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (866545-96-2)

Guidance literature:

5-bromo-1H-pyrrolo[2,3-b]pyridine; With aluminum (III) chloride; In dichloromethane; at 20 ℃; for 1h;

acetyl chloride; In dichloromethane; at 20 ℃; for 18h;

Reference yield: 92.0%

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone (866545-96-2) + (2-trimethylethylsilylethoxy)methyl chloride (76513-69-4) + bis(pinacol)diborane (73183-34-3) → 1-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl-1-2(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanone] (1071454-96-0)

Guidance literature:

1-(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)ethanone; With sodium hydride; In N,N-dimethyl-formamide; at -40 ℃; for 1h;

(2-trimethylethylsilylethoxy)methyl chloride; In N,N-dimethyl-formamide; at -40 ℃; for 2h;

bis(pinacol)diborane; With sodium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In N,N-dimethyl-formamide; at 100 ℃;

upstream raw materials:

acetyl chloride

5-bromo-1H-pyrrolo[2,3-b]pyridine

Downstream raw materials:

1-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl-1-2(2-trimethylsilanyl-ethoxymethyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)-ethanone]

2-(5-bromo-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)propan-2-ol

5-bromo-3-isopropyl-1-tosyl-1H-pyrrolo[2,3-b]pyridine

5-bromo-3-isopropyl-1H-pyrrolo[2,3-b]pyridine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 866545-96-2 1-(5-Bromo-7-azaindole)ethanone

Send

Send

Metric Ton KG G Pound L ML

Send

Send