2-Chloro-5-methyl-3-phenylpyrazine

Base Information

Chemical Name:2-Chloro-5-methyl-3-phenylpyrazine
CAS No.:86725-69-1
Molecular Formula:C11H9ClN2
Molecular Weight:204.659
Hs Code.:
DSSTox Substance ID:DTXSID90521517
Nikkaji Number:J1.175.400G
Wikidata:Q82386034

Synonyms:2-Chloro-5-methyl-3-phenylpyrazine;86725-69-1;SCHEMBL11219513;DTXSID90521517

Suppliers and Price of 2-Chloro-5-methyl-3-phenylpyrazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Chloro-5-methyl-3-phenylpyrazine

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:204.0454260
Heavy Atom Count:14
Complexity:180

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN=C(C(=N1)C2=CC=CC=C2)Cl

Technology Process of 2-Chloro-5-methyl-3-phenylpyrazine

There total 9 articles about 2-Chloro-5-methyl-3-phenylpyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 74428-46-9
2-methyl-6-phenylpyrazine 1-oxide

: 81225-11-8
2-chloro-3-methyl-5-phenylpyrazine

: 86725-69-1
5-chloro-2-methyl-6-phenylpyrazine

Guidance literature:: With trichlorophosphate; for 1h; Heating;

Reference yield: 22.0%

: 74428-47-0
2-methyl-6-phenylpyrazine 4-oxide

: 81225-11-8
2-chloro-3-methyl-5-phenylpyrazine

: 86725-69-1
5-chloro-2-methyl-6-phenylpyrazine

Guidance literature:: With trichlorophosphate; for 0.5h; Heating;

Reference yield:

: 81225-11-8
2-chloro-3-methyl-5-phenylpyrazine

: 86725-69-1
5-chloro-2-methyl-6-phenylpyrazine

Guidance literature:: Multi-step reaction with 6 steps

1: 18 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1.) room temperature, overnight; 2.) reflux, 3 h

2: 95 percent / tetrakis(triphenylphosphine)palladium, sodium formate / dimethylformamide / 2 h / 100 °C

3: 31 percent / POCl₃ / 1 h / Heating

4: 74 percent / H₂, sodium acetate / 20percent Pd carbon / ethanol

5: 79 percent / 90percent H₂O₂, maleic anhydride / CHCl₃ / 1.) overnight; 2.) reflux, 4 h

6: 22 percent / POCl₃ / 0.5 h / Heating

With maleic anhydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; dihydrogen peroxide; sodium formate; sodium acetate; trichlorophosphate; palladium on activated charcoal; In ethanol; chloroform; N,N-dimethyl-formamide;