Technology Process of Phosphine oxide,
diphenyl(spiro[bicyclo[4.2.0]oct-1(6)-ene-3,2'-[1,3]dioxolan]-8-ylmethyl)-
There total 3 articles about Phosphine oxide,
diphenyl(spiro[bicyclo[4.2.0]oct-1(6)-ene-3,2'-[1,3]dioxolan]-8-ylmethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1) EtOH, Na, liq.NH3 2) toluene-p-sulfonic acid / 1) THF, -78 deg C 2) CH2Cl2, r.t., 1 h
2: pyridine / 1 h / Ambient temperature
3: NaBr / dimethylformamide / 2 h / 80 - 85 °C
4: 2) 5 percent hydrogen peroxide / 1) THF, -20 deg C, 10 min 2) CHCl3, room temperature, 30 min
With
pyridine; ethanol; ammonia; dihydrogen peroxide; sodium; toluene-4-sulfonic acid; sodium bromide;
In
N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91875-7
- Guidance literature:
-
Multi-step reaction with 2 steps
1: NaBr / dimethylformamide / 2 h / 80 - 85 °C
2: 2) 5 percent hydrogen peroxide / 1) THF, -20 deg C, 10 min 2) CHCl3, room temperature, 30 min
With
dihydrogen peroxide; sodium bromide;
In
N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91875-7
- Guidance literature:
-
With
dihydrogen peroxide;
Yield given. Multistep reaction;
1) THF, -20 deg C, 10 min 2) CHCl3, room temperature, 30 min;
DOI:10.1016/S0040-4020(01)91875-7
