Hexanoic acid, 6-[[3-[[4-[(3,3-diphenylpropyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]butyl] [(2,4,6-trimethylphenyl)sulfonyl]amino]propyl]amino]-6-oxo-

Base Information

• Chemical Name: Hexanoic acid, 6-[[3-[[4-[(3,3-diphenylpropyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]butyl] [(2,4,6-trimethylphenyl)sulfonyl]amino]propyl]amino]-6-oxo-
• CAS No.: 868836-22-0
• Molecular Formula: C46H61N3O7S2
• Molecular Weight: 832.138
• Mol file: 868836-22-0.mol

Synonyms:

Chemical Property of Hexanoic acid, 6-[[3-[[4-[(3,3-diphenylpropyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]butyl] [(2,4,6-trimethylphenyl)sulfonyl]amino]propyl]amino]-6-oxo-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Hexanoic acid, 6-[[3-[[4-[(3,3-diphenylpropyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]butyl] [(2,4,6-trimethylphenyl)sulfonyl]amino]propyl]amino]-6-oxo-

There total 6 articles about Hexanoic acid, 6-[[3-[[4-[(3,3-diphenylpropyl)[(2,4,6-trimethylphenyl)sulfonyl]amino]butyl] [(2,4,6-trimethylphenyl)sulfonyl]amino]propyl]amino]-6-oxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid methyl ester (868836-18-4) → 15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid (868836-22-0)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm0505009

Reference yield: 80.0%

→ 15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid (868836-22-0)

Guidance literature:

Reference yield:

C33H41N3O6S2 → 15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid (868836-22-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 60.3 percent / dimethylformamide / 12 h

2.1: 78.5 percent / hydrazine / methanol / 12 h / Heating

3.1: 72.6 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4.1: 80 percent / aq. LiOH / tetrahydrofuran / 0 - 20 °C

With lithium hydroxide; sodium hydride; triethylamine; hydrazine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm0505009

upstream raw materials:

15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid methyl ester

1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

1-phthalimido-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

1-chloro-3,3-diphenylpropane

Downstream raw materials:

15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanohydroxamic acid