1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

Base Information

• Chemical Name: 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane
• CAS No.: 868836-14-0
• Molecular Formula: C₄₀H₅₃N₃O₄S₂
• Molecular Weight: 704.011
• Mol file: 868836-14-0.mol

Synonyms:1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

Chemical Property of 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

There total 4 articles about 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.5%

1-phthalimido-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane (868836-12-8) → 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane (868836-14-0)

Guidance literature:

With hydrazine; In methanol; for 12h; Heating;

DOI:10.1021/jm0505009

Reference yield: 78.5%

→ 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane (868836-14-0)

Guidance literature:

Reference yield:

C33H41N3O6S2 → 1-amino-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane (868836-14-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide / 0.5 h / 0 °C

1.2: 60.3 percent / dimethylformamide / 12 h

2.1: 78.5 percent / hydrazine / methanol / 12 h / Heating

With sodium hydride; hydrazine; In methanol; N,N-dimethyl-formamide;

DOI:10.1021/jm0505009

upstream raw materials:

1-phthalimido-4-{N-[2,4,6-(trimethyl)benzenesulfonyl]}-8-{N-[3,3-(diphenyl)propyl]-N-[2,4,6-(trimethyl)benzenesulfonyl]}amino-4-azaoctane

1-chloro-3,3-diphenylpropane

Downstream raw materials:

17-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-13-[N-2,4,6-(trimethyl)benzenesulfonyl]-8-oxo-7,11-diazaheptadecanohydroxamic acid

17-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-13-[N-2,4,6-(trimethyl)benzenesulfonyl]-8-oxo-7,11-diazaheptadecanoic acid

15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanohydroxamic acid

15-{N-[2,4,6-(trimethyl)benzenesulfonyl]-N-[3,3-(diphenyl)propyl]}amino-11-[N-2,4,6-(trimethyl)benzenesulfonyl]-6-oxo-7,11-diazapentadecanoic acid