(17beta)-2,3-dihydroxyestra-1(10),2,4-trien-17-yl acetate

Base Information Edit

Chemical Name:(17beta)-2,3-dihydroxyestra-1(10),2,4-trien-17-yl acetate
CAS No.:23463-05-0
Molecular Formula:C20H26 O4
Molecular Weight:330.424
Hs Code.:
Mol file:23463-05-0.mol

Synonyms:Estra-1,3,5(10)-triene-2,3,17b-triol, 17-acetate (6CI,8CI);2-Hydroxyestradiol 17-acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (17beta)-2,3-dihydroxyestra-1(10),2,4-trien-17-yl acetate Edit

Chemical Property:

Vapor Pressure:6.13E-10mmHg at 25°C
Melting Point:181 °C
Boiling Point:482.6°Cat760mmHg
PKA:10.11±0.60(Predicted)
Flash Point:169.4°C
PSA：66.76000
Density:1.25g/cm³
LogP:3.88560

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (17beta)-2,3-dihydroxyestra-1(10),2,4-trien-17-yl acetate

There total 11 articles about (17beta)-2,3-dihydroxyestra-1(10),2,4-trien-17-yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 26362-44-7
2-acetyl-estra-1,3,5(10)-triene-3,17β-diol 17-acetate

: 23463-05-0
estra-1,3,5(10)-triene-2,3,17β-triol-17-acetate

Guidance literature:: With sodium hydroxide; dihydrogen peroxide; In diethylene glycol dimethyl ether; for 30h; Ambient temperature;
DOI:10.1016/0039-128X(82)90016-2

Reference yield:

: 50-28-2
estradiol

: 23463-05-0
estra-1,3,5(10)-triene-2,3,17β-triol-17-acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 57.3 percent / AlCl₃ / chlorobenzene / 1) 0 deg C, 3 h, 2) r.t. to 40 deg C

2: 85.2 percent / 1 N NaOH, 6percent H₂O₂ / bis-(2-methoxy-ethyl) ether / 30 h / Ambient temperature

With sodium hydroxide; aluminium trichloride; dihydrogen peroxide; In diethylene glycol dimethyl ether; chlorobenzene;
DOI:10.1016/0039-128X(82)90016-2