3-Methyl-4-phenylfurazan

Base Information

• Chemical Name: 3-Methyl-4-phenylfurazan
• CAS No.: 10349-09-4
• Molecular Formula: C9H8 N2 O
• Molecular Weight: 160.175
• European Community (EC) Number: 866-120-8
• DSSTox Substance ID: DTXSID10145875
• Nikkaji Number: J507.975F
• Wikidata: Q83010560
• Mol file: 10349-09-4.mol

Synonyms:3-methyl-4-phenyl-1,2,5-oxadiazole;3-Methyl-4-phenylfurazan;10349-09-4;Methylphenylfurazan;Methyl-phenyl-1,2,5-oxdiazol;SCHEMBL10166465;DTXSID10145875;AKOS033384864;CS-0223746;EN300-116534;Z1238570891

Chemical Property of 3-Methyl-4-phenylfurazan

Chemical Property:

• Vapor Pressure: 0.0324mmHg at 25°C
• Boiling Point: 251.5°Cat760mmHg
• Flash Point: 104.2°C
• Density: 1.142g/cm³
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 146

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NON=C1C2=CC=CC=C2

Technology Process of 3-Methyl-4-phenylfurazan

There total 7 articles about 3-Methyl-4-phenylfurazan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3-methyl-4-phenylfuroxan (6898-86-8) → 3-phenyl-4-methylfurazan (10349-09-4)

Guidance literature:

With triethyl phosphite; for 3h; Reflux;

DOI:10.1016/j.tet.2015.01.031

Reference yield:

1-phenyl-propanedione-(1.2)-1-seqcis-oxime-2-seqtrans-oxime (4937-86-4,17019-18-0,29842-19-1) → 3-phenyl-4-methylfurazan (10349-09-4)

Guidance literature:

With sulfuric acid; at 100 ℃;

Reference yield:

phenylmethylglyoxime diacetate → 3-phenyl-4-methylfurazan (10349-09-4)

Guidance literature:

With sodium hydroxide; for 2h; Yield given; Heating;

DOI:10.1007/BF00513282

upstream raw materials:

1-phenyl-propanedione-(1.2)-1-seqcis-oxime-2-seqtrans-oxime

α-methylphenylglyoxime-O.O diacetate

3-methyl-4-phenylfuroxan

phosphorus pentachloride

Downstream raw materials:

3-(4'-nitrophenyl)-4-methylfurazan

3-(2,4-Dinitro-phenyl)-4-methyl-furazan

3-(2'-nitrophenyl)-4-methylfurazan

3-(3'-nitrophenyl)-4-methylfurazan

Refernces

• 1、 Zhao, Jian-Qiang,Zhou, Ming-Qiang,Zuo, Jian,Xu, Xiao-Ying,Zhang, Xiao-Mei,Yuan, Wei-Cheng. "Synthesis of furoxan derivatives: DABCO-mediated cascade sulfonylation/cyclization reaction of α-nitro-ketoximes". . p. 1560 - 1565. Retrieved 2015/03/04.