6898-86-8Relevant academic research and scientific papers
Synthesis of Furoxans (1,2,5-oxadiazole 2-oxides) from Styrenes and Nitrosonium Tetrafluoroborate in Non-Acidic Media and Mechanistic Study
Matsubara, Ryosuke,Ando, Akihiro,Saeki, Yuta,Eda, Kazuo,Asada, Naoki,Tsutsumi, Tomoaki,Shin, Yong Soon,Hayashi, Masahiko
, p. 1094 - 1105 (2016/07/29)
Diverse furoxans (1,2,5-oxadiazole 2-oxides) were synthesized from the corresponding styrenes using nitrosonium tetrafluoroborate as the nitrosation reagent in pyridine (basic media) or dichloromethane (neutral media). Acid-sensitive functional groups were tolerated under these conditions. The probable reaction mechanism was elucidated. The experimental results support an ionic reaction pathway in contrast to the conventional acidic conditions with a radical mechanism.
Method for synthesizing furazan oxide compound
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Paragraph 0018-0020, (2017/03/22)
The invention discloses a method for synthesizing a furazan oxide compound and belongs to the field of organic chemistry and can be applied to the field of medicine. According to the method, triethylenediamine hexahydrate (DABCO.6HO) serves as organic alkali for catalyzing a reaction between alpha-nitroxime and sulfonyl chloride and is used for synthesizing the furazan oxide compound. The method has the advantages of being mild in reaction condition, high in reaction speed, high in yield and the like and is a synthetic method which is of extremely high industrialization value.
Synthesis of furoxan derivatives: DABCO-mediated cascade sulfonylation/cyclization reaction of α-nitro-ketoximes
Zhao, Jian-Qiang,Zhou, Ming-Qiang,Zuo, Jian,Xu, Xiao-Ying,Zhang, Xiao-Mei,Yuan, Wei-Cheng
, p. 1560 - 1565 (2015/03/04)
A convenient and efficient method for the synthesis of furoxan derivatives from α-nitro-ketoximes and sulfonyl chlorides is reported. A wide variety of furoxan derivatives were smoothly obtained in good yields via a DABCO-mediated cascade sulfonylation/cy
Synthesis of furoxans from styrenes under basic or neutral conditions
Matsubara, Ryosuke,Saeki, Yuta,Li, Jianhua,Eda, Kazuo
, p. 1524 - 1528 (2013/07/05)
Furoxans (1,2,5-oxadiazole 2-oxides) can be synthesized from the corresponding styrenes using NOBF4 under basic or even almost neutral reaction conditions. Acid-sensitive functional groups are tolerated under the developed basic conditions. For
