1-N-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

Base Information

• Chemical Name: 1-N-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE
• CAS No.: 871112-37-7
• Molecular Formula: C16H22ClNO3
• Molecular Weight: 311.809
• Mol file: 871112-37-7.mol

Synonyms:1-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE;4-(3-chloro-phenyl)-4-hydroxy-piperidine-1-carboxylic acid tert-butyl ester;tert-butyl 4-hydroxy-4-(3-chloro-phenyl)-piperidine-1-carboxylate;

Chemical Property of 1-N-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

Chemical Property:

• PSA: 49.77000
• LogP: 3.49640

Purity/Quality:

99% ^*data from raw suppliers

1-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-N-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE

There total 4 articles about 1-N-BOC-4-(3-CHLOROPHENYL)-4-HYDROXYPIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

1-bromo-3-chlorobenzene (108-37-2) + N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(3-chlorophenyl)-4-hydroxypiperidine-1-carboxylate (871112-37-7)

Guidance literature:

1-bromo-3-chlorobenzene; With magnesium; iodine; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; Saturated solution;

Reference yield: 59.0%

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) + (3-chlorophenyl)magnesium bromide (36229-42-2) → tert-butyl 4-(3-chlorophenyl)-4-hydroxypiperidine-1-carboxylate (871112-37-7)

Guidance literature:

(3-chlorophenyl)magnesium bromide; With lithium chloride; In tetrahydrofuran; for 0.25h; Inert atmosphere;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran; at 20 ℃; for 2.5h; Inert atmosphere;

Reference yield:

N-tert-butyloxycarbonylpiperidin-4-one (79099-07-3) → tert-butyl 4-(3-chlorophenyl)-4-hydroxypiperidine-1-carboxylate (871112-37-7)

Guidance literature:

m-ClC₆H₄Hal; With magnesium; In tetrahydrofuran;

N-tert-butyloxycarbonylpiperidin-4-one; In tetrahydrofuran;

DOI:10.1016/S0968-0896(01)00005-0

upstream raw materials:

N-tert-butyloxycarbonylpiperidin-4-one

(3-chlorophenyl)magnesium bromide

1-bromo-3-chlorobenzene

Downstream raw materials:

tert-butyl 4-(3-chloro-phenyl)-4-(2-pyrrolidin-1-ylethoxy)-piperidine-1-carboxylate

4-(4-bromo-phenyl)-4-(3-chloro-phenyl)-piperidine hydrochloride

tert-butyl 4-(3-chlorophenyl)-5,6-dihydropyridine-1(2H)-carboxylate

4-(3-chlorophenyl)piperidin-4-ol

Refernces

• 1、 Fyfe, Tim J.,Kellam, Barrie,Sykes, David A.,Capuano, Ben,Scammells, Peter J.,Lane, J. Robert,Charlton, Steven J.,Mistry, Shailesh N.. "Structure-Kinetic Profiling of Haloperidol Analogues at the Human Dopamine D2 Receptor". . p. 9488 - 9520. Retrieved 2019/11/11.
• 2、 -. "SUBSTITUTED SULFONAMIDE COMPOUNDS". Page/Page column 97. . Retrieved 2009/10/30.