Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2-amino-4-chloro-, methyl ester

Base Information

• Chemical Name: Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2-amino-4-chloro-, methyl ester
• CAS No.: 871231-32-2
• Molecular Formula: C8H6ClN3O2S
• Molecular Weight: 243.67000
• Hs Code.: 2934999090

Synonyms:2-Amino-4-chloro-thieno[2,3-d]pyrimidine-6-carboxylic acid methyl ester;

Chemical Property of Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2-amino-4-chloro-, methyl ester

Chemical Property:

• Melting Point: 246 - 249 °C (H2O)
• PSA: 106.34000
• LogP: 2.29470

Purity/Quality:

99%, ^*data from raw suppliers

Methyl 2-amino-4-chlorothieno[2,3-d]pyrimidine-6-carboxylate ^*data from reagent suppliers

Safty Information:

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Technology Process of Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2-amino-4-chloro-, methyl ester

There total 3 articles about Thieno[2,3-d]pyrimidine-6-carboxylic acid, 2-amino-4-chloro-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

methyl [(2-amino-4-chloro-5-formyl-6-pyrimidinyl)thio]ethanoate (873544-78-6) → methyl 2-amino-4-chlorothieno[2,3-d]pyrimidine-6-carboxylate (871231-32-2)

Guidance literature:

With triethylamine; In methanol; for 18h; Heating;

DOI:10.1002/jhet.5570420709

Reference yield:

Methyl thioglycolate (2365-48-2) + 2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (5604-46-6) → methyl 2-amino-4-chlorothieno[2,3-d]pyrimidine-6-carboxylate (871231-32-2)

Guidance literature:

With potassium carbonate; In acetonitrile; Heating / reflux;

Reference yield:

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde (5604-46-6) → methyl 2-amino-4-chlorothieno[2,3-d]pyrimidine-6-carboxylate (871231-32-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 66 percent / Et₃N / aq. methanol / 1.5 h / 20 °C

2: 71 percent / Et₃N / methanol / 18 h / Heating

With triethylamine; In methanol;

DOI:10.1002/jhet.5570420709

upstream raw materials:

methyl [(2-amino-4-chloro-5-formyl-6-pyrimidinyl)thio]ethanoate

2-amino-4,6-dichloropyrimidine-5-carboxaldehyde

Methyl thioglycolate

Downstream raw materials:

methyl 2-amino-4-[(4-fluorophenyl)amino]thieno[2,3-d]pyrimidine-6-carboxylate

2-amino-4-methoxy-thieno[2,3-d]pyrimidine-6-carboxylic acid (3,4,5-trimethoxy-phenyl)-amide

2-amino-4-methoxy-thieno[2,3-d]pyrimidine-6-carboxylic acid (4-methoxy-phenyl)-amide

2-amino-4-methoxythieno[2,3-d]pyrimidine-6-carboxylic acid

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