4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE

Base Information

• Chemical Name: 4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE
• CAS No.: 872626-76-1
• Molecular Formula: C₇H₄F₃NO
• Molecular Weight: 175.11
• Mol file: 872626-76-1.mol

Synonyms:4-(TRIFLUOROMETHYL)NICOTINALDEHYDE;4-Trifluoromethyl-pyridine-3-carbaldehyde;4-Trifluoromethyl-3-pyridine carbaldehyde;4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE;

Chemical Property of 4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE

Chemical Property:

• Vapor Pressure: 0.0475mmHg at 25°C
• Boiling Point: 236.4oC at 760 mmHg
• Flash Point: 96.8oC
• PSA: 29.96000
• Density: 1.369g/cm3
• LogP: 1.91290

Purity/Quality:

99%+ ^*data from raw suppliers

4-(TRIFLUOROMETHYL)NICOTINALDEHYDE 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,T
• Statements: 25-36-43
• Safety Statements: 26-36/37-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE

There total 8 articles about 4-TRIFLUOROMETHYL-3-FORMYLPYRIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-(trifluoromethyl)pyridin-3-ylmethanol (386704-04-7) → 6-(trifluoromethyl)pyridine-3-carbaldehyde (386704-12-7,872626-76-1)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; at 0 - 20 ℃;

Reference yield: 50.0%

2,2-diethoxy acetic acid (20461-86-3) + 5-bromo-2(trifluoromethyl)pyridine (436799-32-5) → 6-(trifluoromethyl)pyridine-3-carbaldehyde (386704-12-7,872626-76-1)

Guidance literature:

With nickel(II) chloride hexahydrate; (4s,6s)-2,4,5,6-tetra(9H-carbazol-9-yl)isophthalonitrile; caesium carbonate; 4,4'-di-tert-butyl-2,2'-bipyridine; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Schlenk technique; Inert atmosphere; Irradiation;

DOI:10.1002/anie.201610108

Reference yield:

N,N-dimethyl-formamide (68-12-2,33513-42-7) + 5-bromo-2(trifluoromethyl)pyridine (436799-32-5) → 6-(trifluoromethyl)pyridine-3-carbaldehyde (386704-12-7,872626-76-1)

Guidance literature:

With n-butyllithium; In hexane; at 10 ℃; for 2h; Inert atmosphere;

upstream raw materials:

6-(trifluoromethyl)pyridin-3-ylmethanol

6-trifluoromethylnicotinic acid

N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide

Methyl formate

Downstream raw materials:

(R)-2-hydroxy-2-(6-(trifluoromethyl)pyridin-3-yl)ethyl 4-methylbenzenesulfonate

(S)-2-amino-2-(6-(trifluoromethyl)pyridin-3-yl)ethanol