1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-

Base Information

Chemical Name:1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-
CAS No.:872674-52-7
Molecular Formula:C27H28ClNO
Molecular Weight:417.978
Hs Code.:
DSSTox Substance ID:DTXSID50467927
Wikidata:Q82295014

Synonyms:872674-52-7;1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-;DTXSID50467927

Suppliers and Price of 1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-

Chemical Property:

XLogP3:7.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:6
Exact Mass:417.1859422
Heavy Atom Count:30
Complexity:516

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)C1=C(C2=C(N1C(C3=CC=CC=C3)C4=CC=CC=C4)C=CC(=C2)Cl)CCO

Technology Process of 1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)-

There total 7 articles about 1H-Indole-3-ethanol, 5-chloro-2-(1,1-dimethylethyl)-1-(diphenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 872674-49-2
2-(2-tert-butyl-5-chloro-1H-indol-3-yl)ethanol

: 776-74-9
Bromodiphenylmethane

: 872674-52-7
2-[2-tert-butyl-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethanol

Guidance literature:: 2-(2-tert-butyl-5-chloro-1H-indol-3-yl)ethanol; With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 0.5h;

Bromodiphenylmethane; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/jm0507882

Reference yield:

: N-(4-chloro-phenyl)-N'-(1,2,2-trimethyl-propylidene)-hydrazine

: 872674-52-7
2-[2-tert-butyl-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: ZnCl₂ / 140 °C

2.1: diethyl ether / 0.5 h / cooling

3.1: NEt₃ / diethyl ether

4.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 10 °C

5.1: NaH / dimethylformamide / 0.5 h / 0 °C

5.2: dimethylformamide / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; zinc(II) chloride; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide; 1.1: Fischer indole synthesis;
DOI:10.1021/jm0507882

Reference yield:

: (2-tert-butyl-5-chloro-1H-indol-3-yl)-oxo-acetyl chloride

: 872674-52-7
2-[2-tert-butyl-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NEt₃ / diethyl ether

2.1: LiAlH₄ / tetrahydrofuran / 0.5 h / 10 °C

3.1: NaH / dimethylformamide / 0.5 h / 0 °C

3.2: dimethylformamide / 0 - 20 °C

With lithium aluminium tetrahydride; sodium hydride; triethylamine; In tetrahydrofuran; diethyl ether; N,N-dimethyl-formamide;
DOI:10.1021/jm0507882