4-BroMo-6-Methoxyquinoline-3-carboxylicacid

Base Information

• Chemical Name: 4-BroMo-6-Methoxyquinoline-3-carboxylicacid
• CAS No.: 872714-51-7
• Molecular Formula: C₁₁H₈BrNO₃
• Molecular Weight: 282.093
• Hs Code.: 2933499090
• Mol file: 872714-51-7.mol

Synonyms:4-bromo-6-methoxy-quinoline-3-carboxylic acid;4-bromo-6-(methyloxy)-3-quinolinecarboxylic acid;

Chemical Property of 4-BroMo-6-Methoxyquinoline-3-carboxylicacid

Chemical Property:

• PSA: 59.42000
• LogP: 2.70410
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

4-Bromo-6-methoxyquinoline-3-carboxylic acid 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-BroMo-6-Methoxyquinoline-3-carboxylicacid

There total 4 articles about 4-BroMo-6-Methoxyquinoline-3-carboxylicacid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4-bromo-6-methoxy-quinoline-3-carboxylic acid ethyl ester (872714-50-6) → 4-bromo-6-methoxy-quinoline-3-carboxylic acid (872714-51-7)

Guidance literature:

4-bromo-6-methoxy-quinoline-3-carboxylic acid ethyl ester; With sodium hydroxide; water; In tetrahydrofuran; for 24h;

With hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

4-methoxy-aniline (104-94-9) → 4-bromo-6-methoxy-quinoline-3-carboxylic acid (872714-51-7)

Guidance literature:

Multi-step reaction with 4 steps

1: ethanol / 4 h / 85 °C

2: Dowtherm A / 3 h / 250 °C

3: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C

4: sodium hydroxide / tetrahydrofuran / 0 - 20 °C

With Dowtherm A; phosphorus tribromide; sodium hydroxide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

Reference yield:

diethyl 2-(((4-methoxyphenyl)amino)methylene)malonate (83507-70-4) → 4-bromo-6-methoxy-quinoline-3-carboxylic acid (872714-51-7)

Guidance literature:

Multi-step reaction with 3 steps

1: Dowtherm A / 3 h / 250 °C

2: phosphorus tribromide / N,N-dimethyl-formamide / 1 h / 20 °C

3: sodium hydroxide / tetrahydrofuran / 0 - 20 °C

With Dowtherm A; phosphorus tribromide; sodium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;

upstream raw materials:

4-bromo-6-methoxy-quinoline-3-carboxylic acid ethyl ester

4-methoxy-aniline

diethyl 2-(((4-methoxyphenyl)amino)methylene)malonate

ethyl 4-hydroxy-6-methoxyquinoline-3-carboxylate

Downstream raw materials:

4-bromo-6-methoxyquinolin-3-amine

(4-bromo-6-methoxy-quinolin-3-yl)-carbamic acid tert-butyl ester

6-methoxy-4-(2-(4-(4-nitrobenzylamino)piperidin-1-yl)ethyl)quinoline-3-carbonitrile

4-(2-(4-(4-hydroxy-3-methoxybenzylamino)piperidin-1-yl)ethyl)-6-methoxyquinoline-3-carbonitrile

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