1-Azido-4-methoxybenzene

Base Information

• Chemical Name: 1-Azido-4-methoxybenzene
• CAS No.: 2101-87-3
• Molecular Formula: C7H7N3O
• Molecular Weight: 149.152
• Hs Code.: 2929909090
• European Community (EC) Number: 861-804-2
• DSSTox Substance ID: DTXSID50175217
• Nikkaji Number: J113.339J
• Wikidata: Q83045496
• ChEMBL ID: CHEMBL3236175
• Mol file: 2101-87-3.mol

Synonyms:1-Azido-4-methoxybenzene;2101-87-3;Anisole, p-azido-;Benzene, 1-azido-4-methoxy-;4-Methoxyphenyl azide;p-Methoxyphenyl azide;p-Azidoanisole;1-azido-4-methoxy-benzene;CHEMBL3236175;SCHEMBL13449657;DTXSID50175217;AKOS015830673;EN300-112654

Chemical Property of 1-Azido-4-methoxybenzene

Chemical Property:

• Melting Point: 36 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 58.98000
• Density: g/cm³
• LogP: 2.08976
• Storage Temp.: ?20°C
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 149.058911855
• Heavy Atom Count: 11
• Complexity: 157

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-Azido-4-methoxybenzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s): 3609304
• Hazard Codes: F,Xi
• Statements: 11-38-43
• Safety Statements: 16-36/37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)N=[N+]=[N-]

Technology Process of 1-Azido-4-methoxybenzene

There total 53 articles about 1-Azido-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-methoxy-aniline (104-94-9) → p-methoxy-phenylazide (2101-87-3)

Guidance literature:

With tert.-butylnitrite; trimethylsilylazide; In acetonitrile; at 0 - 20 ℃; for 1h;

DOI:10.1039/c3cc43838d

Reference yield: 99.0%

para-iodoanisole (696-62-8) → p-methoxy-phenylazide (2101-87-3)

Guidance literature:

With sodium azide; In ethylene glycol; at 100 ℃; for 3h; Green chemistry;

DOI:10.1039/c8ra04608e

Reference yield: 99.0%

1-bromo-4-methoxy-benzene (104-92-7) → p-methoxy-phenylazide (2101-87-3)

Guidance literature:

With sodium azide; In ethylene glycol; at 100 ℃; for 3h; Green chemistry;

DOI:10.1039/c8ra04608e

upstream raw materials:

1-(4-methoxy-phenylazo)-aziridine

4-methoxynitrosobenzene

4-methoxy-aniline

p-methoxyphenyl trifluoroacetate

Downstream raw materials:

1-(4-methoxyphenyl)-4-phenyl-1H-1,2,3-triazol-5-amine

1-(1-p-methoxyphenyl-1H-1,2,3-triazol-4-yl)ethanone

1-(4-Methoxyphenyl)-5-(N-methyl-N-acetamido)-1,2,3-triazoline

2-Chloro-1-[1-(4-methoxy-phenyl)-1H-[1,2,3]triazol-4-yl]-ethanone

Refernces

• 1、 Gondru, Ramesh,Kanugala, Sirisha,Raj, Sneha,Ganesh Kumar,Pasupuleti, Mukesh,Banothu, Janardhan,Bavantula, Rajitha. "1,2,3-triazole-thiazole hybrids: Synthesis, in vitro antimicrobial activity and antibiofilm studies". . . Retrieved 2021.
• 2、 Schroer, Thorsten,Haiges, Ralf,Schneider, Stefan,Christe, Karl O.. "The race for the first generation of the pentazolate anion in solution is far from over". . p. 1607 - 1609. Retrieved 2005.
• 3、 Cleemann, Felix,Karuso, Peter,Kum-Cheung, Wendy Loa. "Combinatorial synthesis of new fluorescent scaffolds using click chemistry". supporting information. . Retrieved 2021/12/08.
• 4、 Huang, Ming-Jie,Guo, Jia-Wen,Fu, Yun-Dong,You, Ya-Zhen,Xu, Wen-Yu,Song, Ting-Yu,Li, Ran,Chen, Zi-Tong,Huang, Li-Hua,Liu, Hong-Min. "Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors". supporting information. . Retrieved 2021/04/12.