Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)-

Base Information

Chemical Name:Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)-
CAS No.:872877-10-6
Molecular Formula:C₂₂H₂₂Cl₂I₂N₂O₇
Molecular Weight:751.141
Hs Code.:

Synonyms:

Suppliers and Price of Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)-

There total 3 articles about Glycine, (2R)-2-(3,5-dichloro-4-hydroxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(4-hydroxy-3,5-diiodophenyl)-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (R)-Amino-(4-hydroxy-3,5-diiodo-phenyl)-acetic acid methyl ester; compound with trifluoro-acetic acid

: 26973-43-3
(R)-2-((tert-butoxycarbonyl)amino)-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 872877-10-6
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-hydroxyphenylglycyl-4'-hydroxy-3',5'-diiodophenylglycine methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; In tetrahydrofuran; dichloromethane; at -5 ℃; for 5h;
DOI:10.1248/cpb.53.1277

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 872877-10-6
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-hydroxyphenylglycyl-4'-hydroxy-3',5'-diiodophenylglycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 77 percent / SO₂Cl₂; aq. HCl; AcOH / 2.5 h / 20 - 70 °C

2: 100 percent / Et₃N / dioxane; H₂O / 1 h / 20 °C

3: 343.8 mg / NMM; HOBt / tetrahydrofuran; CH₂Cl₂ / 5 h / -5 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuryl dichloride; benzotriazol-1-ol; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1248/cpb.53.1277

Reference yield:

: 25698-18-4
(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 872877-10-6
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-hydroxyphenylglycyl-4'-hydroxy-3',5'-diiodophenylglycine methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / Et₃N / dioxane; H₂O / 1 h / 20 °C

2: 343.8 mg / NMM; HOBt / tetrahydrofuran; CH₂Cl₂ / 5 h / -5 °C

With 4-methyl-morpholine; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1248/cpb.53.1277