Glycine, (2R)-2-(3,5-dichloro-4-methoxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(3,5-diiodo-4-methoxyphenyl)-, methyl ester, (2R)-

Base Information

Chemical Name:Glycine, (2R)-2-(3,5-dichloro-4-methoxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(3,5-diiodo-4-methoxyphenyl)-, methyl ester, (2R)-
CAS No.:872877-12-8
Molecular Formula:C24H26Cl2I2N2O7
Molecular Weight:779.195
Hs Code.:

Synonyms:

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Chemical Property of Glycine, (2R)-2-(3,5-dichloro-4-methoxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(3,5-diiodo-4-methoxyphenyl)-, methyl ester, (2R)-

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Technology Process of Glycine, (2R)-2-(3,5-dichloro-4-methoxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(3,5-diiodo-4-methoxyphenyl)-, methyl ester, (2R)-

There total 4 articles about Glycine, (2R)-2-(3,5-dichloro-4-methoxyphenyl)-N-[(1,1-dimethylethoxy)carbonyl] glycyl-2-(3,5-diiodo-4-methoxyphenyl)-, methyl ester, (2R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 872877-10-6
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-hydroxyphenylglycyl-4'-hydroxy-3',5'-diiodophenylglycine methyl ester

: 18107-18-1
diazomethyl-trimethyl-silane

: 872877-12-8
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-methoxyphenylglycyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: In methanol; benzene; at 20 ℃; for 0.05h;
DOI:10.1248/cpb.53.1277

Reference yield:

: 22818-40-2
D-4-hydroxyphenylglycine

: 872877-12-8
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-methoxyphenylglycyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / SO₂Cl₂; aq. HCl; AcOH / 2.5 h / 20 - 70 °C

2: 100 percent / Et₃N / dioxane; H₂O / 1 h / 20 °C

3: 343.8 mg / NMM; HOBt / tetrahydrofuran; CH₂Cl₂ / 5 h / -5 °C

4: 82 percent / methanol; benzene / 0.05 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sulfuryl dichloride; benzotriazol-1-ol; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; benzene;
DOI:10.1248/cpb.53.1277

Reference yield:

: 25698-18-4
(R)-2-amino-2-(3,5-dichloro-4-hydroxyphenyl)acetic acid

: 872877-12-8
(R,R)-N-tert-butoxycarbonyl-3',5'-dichloro-4'-methoxyphenylglycyl-3',5'-diiodo-4'-methoxyphenylglycine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / Et₃N / dioxane; H₂O / 1 h / 20 °C

2: 343.8 mg / NMM; HOBt / tetrahydrofuran; CH₂Cl₂ / 5 h / -5 °C

3: 82 percent / methanol; benzene / 0.05 h / 20 °C

With 4-methyl-morpholine; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; benzene;
DOI:10.1248/cpb.53.1277