Technology Process of D-Tryptophan,
N-[(phenylmethoxy)carbonyl]-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-
2-yl)-, 1,1-dimethylethyl ester
There total 10 articles about D-Tryptophan,
N-[(phenylmethoxy)carbonyl]-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-
2-yl)-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium acetate;
In
dimethyl sulfoxide;
at 77 ℃;
for 3h;
DOI:10.1248/cpb.53.1277
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 96 percent / pyridine / 1.4 h / 20 °C
2: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C
3: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C
4: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C
5: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C
6: 89 percent / AcOH / 2 h / 75 °C
7: 48.3 percent / D-aminocyclase; aq. phosphate buffer; CoCl2 / 47 h / 37 °C / pH 7.4
8: 100 percent / aq. Na2CO3 / diethyl ether / 3 h / 0 °C
9: 82 percent / K2CO3; benzyltriethylammonium chloride / N,N-dimethyl-acetamide / 2.5 h / 55 °C
10: 36.6 percent / Pd(dppf)Cl2; KOAc / dimethylsulfoxide / 3 h / 77 °C
With
pyridine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; phosphate buffer; D-aminocyclase; salcomine; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; oxygen; potassium acetate; sodium carbonate; potassium carbonate; acetic acid; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1248/cpb.53.1277
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 100 percent / H2 / Pd/C / methanol / 1.4 h / 20 °C
2: 62 percent / aq. NaNO2; AcOH; KI / 24 h / 0 °C
3: 71 percent / aq. NaOH / methanol / 4.5 h / 75 °C
4: 98 percent / salcomine; O2 / methanol / 3.5 h / 20 °C
5: 89 percent / AcOH / 2 h / 75 °C
6: 48.3 percent / D-aminocyclase; aq. phosphate buffer; CoCl2 / 47 h / 37 °C / pH 7.4
7: 100 percent / aq. Na2CO3 / diethyl ether / 3 h / 0 °C
8: 82 percent / K2CO3; benzyltriethylammonium chloride / N,N-dimethyl-acetamide / 2.5 h / 55 °C
9: 36.6 percent / Pd(dppf)Cl2; KOAc / dimethylsulfoxide / 3 h / 77 °C
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydroxide; phosphate buffer; D-aminocyclase; salcomine; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; oxygen; potassium acetate; sodium carbonate; potassium carbonate; acetic acid; potassium iodide; sodium nitrite;
palladium on activated charcoal;
In
methanol; diethyl ether; N,N-dimethyl acetamide; dimethyl sulfoxide;
DOI:10.1248/cpb.53.1277
