2-Chloroethyl 2-phenoxyethyl ether

Base Information

• Chemical Name: 2-Chloroethyl 2-phenoxyethyl ether
• CAS No.: 2243-44-9
• Molecular Formula: C10H13 Cl O2
• Molecular Weight: 200.665
• Hs Code.: 2909309090
• European Community (EC) Number: 218-813-6
• NSC Number: 404199,1852
• UNII: X6388FC35L
• DSSTox Substance ID: DTXSID40176955
• Nikkaji Number: J99.632G
• Wikidata: Q83047282
• Mol file: 2243-44-9.mol

Synonyms:2-Chloroethyl 2-phenoxyethyl ether;2243-44-9;Ethane, 1-(2-chloroethoxy)-2-phenoxy-;Benzene, [2-(2-chloroethoxy)ethoxy]-;NSC-1852;EINECS 218-813-6;NSC-404199;Benzene, (2-(2-chloroethoxy)ethoxy)-;AI3-02514;[2-(2-Chloroethoxy)ethoxy]benzene;2-(2-chloroethoxy)ethoxybenzene;NSC1852;O(CCOCCCl)c1ccccc1;SCHEMBL1985916;DTXSID40176955;1-Phenoxy-5-chloro-3-oxapentane;X6388FC35L;NSC 1852;NSC404199;[2-(2-Chloroethoxy)ethoxy]benzene #;NSC 404199

Chemical Property of 2-Chloroethyl 2-phenoxyethyl ether

Chemical Property:

• Vapor Pressure: 0.00295mmHg at 25°C
• Boiling Point: 293.8°Cat760mmHg
• Flash Point: 112.5°C
• PSA: 18.46000
• Density: 1.11g/cm³
• LogP: 2.32080
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 200.0604073
• Heavy Atom Count: 13
• Complexity: 114

Purity/Quality:

99% ^*data from raw suppliers

1-(2-CHLOROETHOXY)-2-PHENOXYETHANE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)OCCOCCCl

Technology Process of 2-Chloroethyl 2-phenoxyethyl ether

There total 5 articles about 2-Chloroethyl 2-phenoxyethyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

sodium phenoxide (139-02-6) + 3-oxa-1,5-dichloropentane (111-44-4) → 2-(2-phenoxyethoxy)ethyl chloride (2243-44-9)

Guidance literature:

In N,N-dimethyl-formamide; at 80 ℃; for 4h;

DOI:10.1246/bcsj.54.2964

Reference yield: 47.0%

1,4-dioxane (123-91-1,28347-88-8,28347-91-3,39449-24-6,54841-74-6) + aniline (62-53-3) → 2-(2-phenoxyethoxy)ethyl chloride (2243-44-9)

Guidance literature:

aniline; With hydrogenchloride; sodium nitrite; In 1,4-dioxane; at 0 - 5 ℃;

1,4-dioxane; With hydrogenchloride; In 1,4-dioxane; at 25 - 30 ℃; for 14h;

Reference yield:

3-oxa-1,5-dichloropentane (111-44-4) + phenol (108-95-2,27073-41-2) → 2-(2-phenoxyethoxy)ethyl chloride (2243-44-9)

Guidance literature:

With sodium hydroxide; copper;

upstream raw materials:

sodium phenoxide

3-oxa-1,5-dichloropentane

phenol

ethanol

Downstream raw materials:

4-[2-(2-phenoxy-ethoxy)-ethyl]-morpholine

1-[2-(2-chloroethoxy)ethoxy]-4-(1,1,3,3-tetramethylbutyl)benzene

5275525 (Hit₂Lead)

2-[2-(2-phenoxyethoxy)ethyl]-4,6-dimethylisothiazolo[5,4-b]pyridin-3(2H)-one

Refernces

• 1、 Ram, Ram N.,Singh, Virinder. "Diazotisation of aromatic amines and solvolysis of diazonium salts in ethylene glycol ethers". . p. 800 - 803. Retrieved 2007/10/03.