Urea, N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1, 2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin- 3-yl]-

Base Information

Chemical Name:Urea, N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1, 2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin- 3-yl]-
CAS No.:873194-94-6
Molecular Formula:C57H64N6O3
Molecular Weight:881.174
Hs Code.:

Urea,
N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1,
2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin-
3-yl]-

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Urea, N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1, 2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin- 3-yl]-

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Technology Process of Urea, N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1, 2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin- 3-yl]-

There total 11 articles about Urea, N-[2,6-bis(1-methylethyl)-4-[(triphenylmethyl)amino]phenyl]-N'-[1-butyl-1, 2-dihydro-2-oxo-4-[3-[3-(1-pyrrolidinyl)propoxy]phenyl]-1,8-naphthyridin- 3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 873194-89-9
1-{1-butyl-4-[3-(3-chloro-propoxy)-phenyl]-2-oxo-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea

: 123-75-1
pyrrolidine

: 873194-94-6
1-{1-butyl-2-oxo-4-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea

Guidance literature:: With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; at 50 ℃; for 10h;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 163704-72-1
4-nitro-2,6-diisopropyl aniline

: 873194-94-6
1-{1-butyl-2-oxo-4-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / methanol / 20 °C

2: Et₃N / CH₂Cl₂ / 20 °C

3: DMAP / tetrahydrofuran / 20 °C

4: 73 percent / K₂CO₃; KI / dimethylformamide / 10 h / 50 °C

With dmap; hydrogen; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056

Reference yield:

: 474328-43-3
N-(2,6-diisopropyl-4-nitrophenyl)-4-methylbenzenesulfonamide

: 873194-94-6
1-{1-butyl-2-oxo-4-[3-(3-pyrrolidin-1-yl-propoxy)-phenyl]-1,2-dihydro-[1,8]naphthyridin-3-yl}-3-[2,6-diisopropyl-4-(trityl-amino)-phenyl]-urea

Guidance literature:: Multi-step reaction with 5 steps

1: 96 percent / H₂SO₄ / 3 h / 70 °C

2: H₂ / Pd/C / methanol / 20 °C

3: Et₃N / CH₂Cl₂ / 20 °C

4: DMAP / tetrahydrofuran / 20 °C

5: 73 percent / K₂CO₃; KI / dimethylformamide / 10 h / 50 °C

With dmap; sulfuric acid; hydrogen; potassium carbonate; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2005.09.056