trans-1-(Boc-aMino)-4-cyanocyclohexane, 97%

Base Information

• Chemical Name: trans-1-(Boc-aMino)-4-cyanocyclohexane, 97%
• CAS No.: 873537-32-7
• Molecular Formula: C12H20N2O2
• Molecular Weight: 224.303
• Hs Code.: 2926909090
• Mol file: 873537-32-7.mol

Synonyms:tert-butyl (4-(aminomethyl)cyclohexyl)carbamate;tert-butyl (trans)-4-cyanocyclohexylcarbamate;trans-tert-butyl 4-(aminomethyl)cyclohexylcarbamate;tert-Butyl (trans-4-(aminomethyl)cyclohexyl)carbamate;tert-Butyl (4-cyanocyclohexyl)carbamate;

Chemical Property of trans-1-(Boc-aMino)-4-cyanocyclohexane, 97%

Chemical Property:

• PSA: 62.12000
• LogP: 2.98438
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

tert-Butyl trans-4-cyanocyclohexylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of trans-1-(Boc-aMino)-4-cyanocyclohexane, 97%

There total 3 articles about trans-1-(Boc-aMino)-4-cyanocyclohexane, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.6%

1,1-dimethylethyl [trans-4-(aminocarbonyl)cyclohexyl]carbamate (643067-91-8) → tert-butyl ((1r,4r)-4-cyanocyclohexyl)carbamate (873537-32-7,1198163-56-2,1303968-12-8)

Guidance literature:

With pyridine; trichlorophosphate; at 0 ℃; for 0.5h;

DOI:10.1021/jm300623u

Reference yield: 54.0%

tert-butyl trans-4-cyanocyclohexane carboxylic acid + tert-butyl alcohol (75-65-0) → tert-butyl ((1r,4r)-4-cyanocyclohexyl)carbamate (873537-32-7,1198163-56-2,1303968-12-8)

Guidance literature:

With diphenylphosphoranyl azide; triethylamine; at 20 ℃; for 6h; Heating / reflux;

Reference yield:

trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid (53292-90-3,130309-46-5,53292-89-0) → tert-butyl ((1r,4r)-4-cyanocyclohexyl)carbamate (873537-32-7,1198163-56-2,1303968-12-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium hydroxide; chloroformic acid ethyl ester; triethylamine / tetrahydrofuran / 1 h / -15 - 20 °C / Inert atmosphere

2: pyridine; trichlorophosphate / 0.5 h / 0 °C

With pyridine; ammonium hydroxide; chloroformic acid ethyl ester; triethylamine; trichlorophosphate; In tetrahydrofuran;

DOI:10.1021/jm300623u

upstream raw materials:

tert-butyl alcohol

1,1-dimethylethyl [trans-4-(aminocarbonyl)cyclohexyl]carbamate

trans-4-(tert-butoxycarbonylamino)cyclohexanoic acid

Downstream raw materials:

trans-4-aminocyclohexanecarbonitrile trifluoroacetic acid salt

2-((trans)-4-cyanocyclohexyl)-3-oxo-N-(4-(trifluoromethoxy)benzyl)isoindoline-1-carboxamide

(1r,4r)-4-aminocyclohexanecarbonitrile

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