(1r,4r)-4-aminocyclohexanecarbonitrile

Base Information

Chemical Name:(1r,4r)-4-aminocyclohexanecarbonitrile
CAS No.:873651-89-9
Molecular Formula:C₇H₁₂N₂
Molecular Weight:124.186
Hs Code.:

Synonyms:(1r,4r)-4-aminocyclohexanecarbonitrile

Suppliers and Price of (1r,4r)-4-aminocyclohexanecarbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemenu
trans-4-Aminocyclohexanecarbonitrile 95%
1g
$ 655.00

ACHEMBLOCK
(1r,4r)-4-aminocyclohexane-1-carbonitrile 97%
250MG
$ 360.00

Total 5 raw suppliers

Chemical Property of (1r,4r)-4-aminocyclohexanecarbonitrile

Chemical Property:

Boiling Point:243.7±33.0 °C(Predicted)
Density:0.99±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

trans-4-Aminocyclohexanecarbonitrile 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1r,4r)-4-aminocyclohexanecarbonitrile

There total 7 articles about (1r,4r)-4-aminocyclohexanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.9%

: 873537-32-7,1198163-56-2,1303968-12-8
tert-butyl ((1r,4r)-4-cyanocyclohexyl)carbamate

: 873651-89-9
(1r,4r)-4-aminocyclohexanecarbonitrile

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: benzyl ((1r,4r)-4-cyanocyclohexyl)carbamate

: 873651-89-9
(1r,4r)-4-aminocyclohexanecarbonitrile

Guidance literature:: benzyl ((1r,4r)-4-cyanocyclohexyl)carbamate; With trimethylsilyl iodide; In dichloromethane; at 0 - 35 ℃; for 2h;

With methanol; In dichloromethane;

Reference yield:

: 1776-53-0,3685-23-2,3685-25-4,57043-03-5,66762-20-7
trans-4-aminocyclohexanecarboxylic acid

: 873651-89-9
(1r,4r)-4-aminocyclohexanecarbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetrahydrofuran; water / 3 h / 0 - 35 °C

2.1: isobutyl chloroformate; 4-methylmorpholine N-oxide / tetrahydrofuran / 1.5 h / -78 °C

2.2: 1.5 h / -78 - 35 °C

3.1: 1H-imidazole; trichlorophosphate; pyridine / 0.5 h / -30 °C

4.1: trimethylsilyl iodide / dichloromethane / 2 h / 0 - 35 °C

With pyridine; 1H-imidazole; trimethylsilyl iodide; 4-methylmorpholine N-oxide; sodium hydroxide; trichlorophosphate; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;