1-O-benzyl-2-O-methylglycerol

Base Information

• Chemical Name: 1-O-benzyl-2-O-methylglycerol
• CAS No.: 121348-74-1
• Molecular Formula: C11H16 O3
• Molecular Weight: 196.246
• Mol file: 121348-74-1.mol

Synonyms:1-Propanol,2-methoxy-3-(phenylmethoxy)-, (?à)-

Chemical Property of 1-O-benzyl-2-O-methylglycerol

Chemical Property:

• Vapor Pressure: 0.000157mmHg at 25°C
• Boiling Point: 317.8°Cat760mmHg
• Flash Point: 146°C
• PSA: 38.69000
• Density: 1.076g/cm³
• LogP: 1.21050

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-O-benzyl-2-O-methylglycerol

There total 5 articles about 1-O-benzyl-2-O-methylglycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

→ 1-O-benzyl-2-O-methyl-rac-glycerol (121348-74-1)

Guidance literature:

Reference yield:

rac-1-O-benzyl-2-O-methyl-3-O-tritylglycerol (121348-73-0) → 1-O-benzyl-2-O-methyl-rac-glycerol (121348-74-1)

Guidance literature:

With acetic acid; for 3h; Yield given; Heating;

DOI:10.1021/jm00129a020

Reference yield:

1-(benzyloxy)-3-(trityloxy)-propan-2-ol (99881-46-6) → 1-O-benzyl-2-O-methyl-rac-glycerol (121348-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaNH₂ / 1) 1,4-dioxane, 1 h, reflux, 2) overnight, reflux

2: 80percent HOAc / 3 h / Heating

With sodium amide; acetic acid;

DOI:10.1021/jm00129a020

upstream raw materials:

3-benzyloxypropan-1,2-diol

methyl iodide

rac-1-O-benzyl-2-O-methyl-3-O-tritylglycerol

1-(benzyloxy)-3-(trityloxy)-propan-2-ol

Downstream raw materials:

1-acetylthio-3-benzyloxy-2-methoxypropane

1-O-[18-(p-iodophenyl)octadecyl]-2-O-methyl-3-O-benzyl-rac-glycerol

1-O-[15-(p-iodophenyl)pentadecyl]-2-O-methyl-3-O-benzyl-rac-glycerol

Refernces

• 1、 -. "Lipid derivatives". . . Retrieved 2008/06/13.