1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-

Base Information

Chemical Name:1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-
CAS No.:873945-22-3
Molecular Formula:C51H68FN3O7Si
Molecular Weight:882.201
Hs Code.:

1-Piperidinecarboxylic acid,
3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4-
[4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth
yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-

Synonyms:

Suppliers and Price of 1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-

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Chemical Property of 1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-

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Technology Process of 1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)-

There total 12 articles about 1-Piperidinecarboxylic acid, 3-[[3,4-dihydro-4-(3-methoxypropyl)-2H-1,4-benzoxazin-6-yl]methoxy]-4- [4-[[(3S)-1-(3-fluorophenyl)-3-pyrrolidinyl]oxy]phenyl]-5-[[tris(1-methyleth yl)silyl]oxy]-, phenylmethyl ester, (3R,4R,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873945-23-4
benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate

: 873945-22-3
benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: With borane-THF; In tetrahydrofuran; at 20 ℃; for 1 - 3h;

Reference yield:

: 1-(3-fluorophenyl)-pyrrolidin-3-ol

: 873945-22-3
benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 24 h / 20 °C

2: caesium carbonate / acetonitrile / 2 h / 80 °C

3: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

4: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C

With dmap; borane-THF; sodium hydride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1-(3-fluorophenyl)pyrrolidin-3-yl p-toluene-4-sulphonate

: 873945-22-3
benzyl 4-{4-[1-(3-fluorophenyl)pyrrolidin-3-yloxy]phenyl}-3-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-5-triisopropylsilanyloxypiperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: caesium carbonate / acetonitrile / 2 h / 80 °C

2: sodium hydride / N,N-dimethyl-formamide / 19 h / -10 - 20 °C

3: borane-THF / tetrahydrofuran / 1 - 3 h / 20 °C

With borane-THF; sodium hydride; caesium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;