4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)-

Base Information

Chemical Name:4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)-
CAS No.:873949-39-4
Molecular Formula:C9H15NO2
Molecular Weight:169.224
Hs Code.:

Synonyms:

Suppliers and Price of 4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)-

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)-

There total 1 articles about 4-Hexynamide, N-methoxy-N,2-dimethyl-, (2S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: (-)-(R)-4-benzyl-3-((S)-2-methylhex-4-ynoyl)oxazolidin-2-one

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 873949-39-4
(+)-(S)-N-methoxy-N,2-dimethylhex-4-ynamide

: (+)-(R)-2-((S)-2-methylhex-4-ynamido)-3-phenylpropyl methoxy(methyl) carbamate

Guidance literature:: With trimethylaluminum; In dichloromethane; toluene; at -10 ℃; for 0.5h;
DOI:10.1021/ja0558037

Reference yield: 79.0%

: 873949-39-4
(+)-(S)-N-methoxy-N,2-dimethylhex-4-ynamide

: 656809-46-0
2,4-dimethoxy-6-methylbenzoic acid 2-trimethylsilanylethyl ester

: 1006608-26-9
C₂₂H₃₂O₅Si

Guidance literature:: 2,4-dimethoxy-6-methylbenzoic acid 2-trimethylsilanylethyl ester; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃;

(+)-(S)-N-methoxy-N,2-dimethylhex-4-ynamide; With N,N,N,N,-tetramethylethylenediamine; In tetrahydrofuran; at -100 - -78 ℃; Further stages.;
DOI:10.1002/anie.200703839

Reference yield:

: 873949-39-4
(+)-(S)-N-methoxy-N,2-dimethylhex-4-ynamide

: beraprost 314d sodium salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexanes / 1 h / 78 °C / Inert atmosphere

1.2: -78 °C

2.1: sodium hydride / tetrahydrofuran / 0 - 10 °C / Inert atmosphere

2.2: 20 °C

3.1: sodium tetrahydroborate; cerium(III) chloride heptahydrate / methanol / 0 - 10 °C

4.1: hydrogenchloride; water / methanol / 20 °C

5.1: sodium hydroxide; water / methanol / 20 - 55 °C

5.2: pH 2 - 3

6.1: sodium hydroxide / water; methanol / 20 °C

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; cerium(III) chloride heptahydrate; water; sodium hydride; sodium hydroxide; In tetrahydrofuran; methanol; hexanes; water;