D-threo-1-phenylglycerol

Base Information

• Chemical Name: D-threo-1-phenylglycerol
• CAS No.: 16354-93-1
• Molecular Formula: C9H12 O3
• Molecular Weight: 168.192
• Mol file: 16354-93-1.mol

Synonyms:1,2,3-Propanetriol,1-phenyl-, D-threo- (8CI); 1,2,3-Propanetriol, 1-phenyl-, [R-(R*,R*)]-;(2R,3R)-2,3-Epoxy-3-phenyl-1-propanol

Chemical Property of D-threo-1-phenylglycerol

Chemical Property:

• Boiling Point: 315°Cat760mmHg
• Flash Point: 156.4°C
• Density: 1.185g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of D-threo-1-phenylglycerol

There total 42 articles about D-threo-1-phenylglycerol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane (133520-57-7) → (1R,2R)-1-phenylpropane-1,2,3-triol (16354-93-1)

Guidance literature:

With hydrogenchloride; In ethanol; for 1.5h; Heating;

Reference yield: 85.0%

3-Phenylpropenol (104-54-1) → (1R,2R)-1-phenylpropane-1,2,3-triol (16354-93-1)

Guidance literature:

With 1,4-bis-(9-O-dihydroquinidinyl)phthalazine; osmium(VIII) oxide; methanesulfonamide; sodium hydrogencarbonate; potassium carbonate; sodium sulfite; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃; for 48h; diastereoselective reaction; Inert atmosphere;

DOI:10.1016/j.tet.2016.04.070

Reference yield:

(2E)-3-phenyl-2-propen-1-ol (4407-36-7) → (1R,2R)-1-phenylpropane-1,2,3-triol (16354-93-1)

Guidance literature:

With (3a,9R,3'''a,4'"b,9'"R)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; osmium(VIII) oxide; methanesulfonamide; potassium carbonate; potassium hexacyanoferrate(III); In water; tert-butyl alcohol; at 0 ℃;

DOI:10.1016/S0040-4039(00)77153-X

upstream raw materials:

(R)-2-((4S,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-[1,3]oxathiolane

(S)-2-((4S,5R)-2,2-Dimethyl-5-phenyl-[1,3]dioxolan-4-yl)-[1,3]oxathiolane

(1S,2R)-1-((1S,4R,6R,8R)-11,11-Dimethyl-5-oxa-3-thia-tricyclo[6.2.1.0^1,6]undec-4-yl)-2-phenyl-ethane-1,2-diol

(4S,5R)-4-(hydroxymethyl)-2,2-dimethyl-5-phenyl-1,3-dioxolane

Downstream raw materials:

C₃₀H₂₄O₆

(1RS,2RS)-1,2,3-tris-benzoyloxy-1-phenyl-propane

5-methoxy-2-(4-nitro-phenyl)-4-phenyl-[1,3]dioxane

2-(4-nitro-phenyl)-4-phenyl-[1,3]dioxan-5-ol