Benzamide, N-[2,4-dimethoxy-5-[[[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-5-methyl phenyl]amino]carbonyl]phenyl]-5-[(2,4-dimethoxy-5-nitrobenzoyl)amino]- 2,4-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-

Base Information

• Chemical Name: Benzamide, N-[2,4-dimethoxy-5-[[[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-5-methyl phenyl]amino]carbonyl]phenyl]-5-[(2,4-dimethoxy-5-nitrobenzoyl)amino]- 2,4-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-
• CAS No.: 874210-60-3
• Molecular Formula: C53H72N4O21
• Molecular Weight: 1101.17
• Mol file: 874210-60-3.mol

Synonyms:

Chemical Property of Benzamide, N-[2,4-dimethoxy-5-[[[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-5-methyl phenyl]amino]carbonyl]phenyl]-5-[(2,4-dimethoxy-5-nitrobenzoyl)amino]- 2,4-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzamide, N-[2,4-dimethoxy-5-[[[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-5-methyl phenyl]amino]carbonyl]phenyl]-5-[(2,4-dimethoxy-5-nitrobenzoyl)amino]- 2,4-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-

There total 17 articles about Benzamide, N-[2,4-dimethoxy-5-[[[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]-5-methyl phenyl]amino]carbonyl]phenyl]-5-[(2,4-dimethoxy-5-nitrobenzoyl)amino]- 2,4-bis[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,4-dimethoxy-5-nitro-benzoic acid methyl ester (81574-75-6) → C53H72N4O21 (874210-60-3)

Guidance literature:

Multi-step reaction with 7 steps

1: 95 percent / NaOH / methanol; H₂O / 0.58 h / Heating

2: oxalyl chloride; DMF / CH₂Cl₂

3: 6.1 g / triethylamine / CH₂Cl₂ / 20 °C

4: H₂ / Pd/C / ethanol; CHCl₃ / 5 h / 40 °C / 0.03 Torr

5: 3.46 g / triethylamine / CH₂Cl₂ / 20 °C

6: H₂ / Pd/C / methanol; CHCl₃ / 5 h / 50 °C / 0.03 Torr

7: 1.83 g / triethylamine / CH₂Cl₂ / 20 °C

With sodium hydroxide; oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform; water;

DOI:10.1021/jo050798a

Reference yield:

2,4-dimethoxy-5-nitrobenzoic acid (90564-41-3) → C53H72N4O21 (874210-60-3)

Guidance literature:

Multi-step reaction with 6 steps

1: oxalyl chloride; DMF / CH₂Cl₂

2: 6.1 g / triethylamine / CH₂Cl₂ / 20 °C

3: H₂ / Pd/C / ethanol; CHCl₃ / 5 h / 40 °C / 0.03 Torr

4: 3.46 g / triethylamine / CH₂Cl₂ / 20 °C

5: H₂ / Pd/C / methanol; CHCl₃ / 5 h / 50 °C / 0.03 Torr

6: 1.83 g / triethylamine / CH₂Cl₂ / 20 °C

With oxalyl dichloride; hydrogen; triethylamine; N,N-dimethyl-formamide; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform;

DOI:10.1021/jo050798a

Reference yield:

2,4-dimethoxy-5-nitro-benzoyl chloride (271261-74-6) → C53H72N4O21 (874210-60-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 6.1 g / triethylamine / CH₂Cl₂ / 20 °C

2: H₂ / Pd/C / ethanol; CHCl₃ / 5 h / 40 °C / 0.03 Torr

3: 3.46 g / triethylamine / CH₂Cl₂ / 20 °C

4: H₂ / Pd/C / methanol; CHCl₃ / 5 h / 50 °C / 0.03 Torr

5: 1.83 g / triethylamine / CH₂Cl₂ / 20 °C

With hydrogen; triethylamine; palladium on activated charcoal; In methanol; ethanol; dichloromethane; chloroform;

DOI:10.1021/jo050798a

upstream raw materials:

2,4-dimethoxy-5-nitro-benzoyl chloride

C₄₄H₆₅N₃O₁₆

2-{2-[2-(2-methoxy-ethoxy)-ethoxy]-ethoxy}-5-methyl-phenylamine

1-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}-4-methyl-2-nitrobenzene

Downstream raw materials:

C₅₃H₇₄N₄O₁₉