90564-41-3

Usage

Uses

Used in Organic Synthesis:
2,4-diMethoxy-5-nitrobenzoic acid is used as a precursor in the synthesis of pharmaceutical drugs and other biologically active compounds. Its functional groups facilitate various chemical reactions, making it a valuable component in the creation of new organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2,4-diMethoxy-5-nitrobenzoic acid serves as a key intermediate in the development of new drugs. Its unique structure allows for the exploration of its potential therapeutic properties and incorporation into medicinal chemistry.
Used in Material and Dye Development:
2,4-diMethoxy-5-nitrobenzoic acid is also utilized in the research and development of new materials and dyes. Its chemical properties make it a candidate for creating novel substances with specific characteristics for various industrial applications.
It is crucial to handle 2,4-diMethoxy-5-nitrobenzoic acid with care due to its potential health and environmental hazards, ensuring safe practices in its use and disposal.

Upstream product

• 91-52-1 2,4 dimethoxybenzoic acid 
• 81574-75-6 2,4-dimethoxy-5-nitro-benzoic acid methyl ester 
• 393-95-3 2-fluoro-4,5-dinitro-benzoic acid 
• 115919-39-6 2-methoxy-4,5-dinitrobenzoic acid 
• 16909-09-4 (E)-3-(2,4-dimethoxyphenyl)-2-propenoic acid 
• 89-86-1 4-hydroxysalicylic acid 
• 13722-96-8 2,4-dihydroxy-5-nitrobenzoic acid 
• 271261-71-3 2,4-dihydroxy-5-nitro-benzoic acid methyl ester 
• 13120-77-9 2-methyl-5-nitroanisole 
• 403-24-7 2-fluoro-4-nitrobenzoic acid 
• 2597-56-0 4-nitro-o-anisic acid 
• 68255-77-6 2-methoxy-4-chloro-5-nitrobenzoic acid 
• 19861-62-2 2,4-dichloro-5-nitrobenzoic acid 
• 124-41-4 sodium methylate 

Downstream Products

• 778599-56-7 1-bromo-2,4-dimethoxy-5-nitrobenzene 
• 174261-19-9 5-amino-2,4-dimethoxy-benzoic acid 
• 271261-78-0 3-(5-(2,4-dimethoxy-5-nitrobenzoylamino)-2,4-dioctyloxybenzoylamino)-4-methoxytoluene 
• 81574-75-6 2,4-dimethoxy-5-nitro-benzoic acid methyl ester 
• 1383808-78-3 C₄₉H₈₀N₂O₉ 
• 1383808-79-4 C₃₁H₄₄N₂O₁₅ 
• 1383808-80-7 C₄₈H₇₈N₂O₉ 
• 1383808-81-8 C₃₀H₄₂N₂O₁₅ 
• 1383808-65-8 C₄₉H₈₂N₂O₇ 
• 1383808-70-5 C₆₁H₈₆N₄O₂₇ 
• 214470-27-6 7-methoxy-4-hydroxy-6-nitroquinoline-3-carbonitrile 
• 214470-33-4 4-chloro-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214485-59-3 4-(3-Chloro-4-fluoro-phenylamino)-7-methoxy-6-nitro-quinoline-3-carbonitrile 
• 214485-60-6 6-amino-4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinoline-3-carbonitrile 

Relevant academic research and scientific papers

4-quinazoline amine derivatives and their use

A 4-quinazoline amine derivative as represented by formula (1), a pharmaceutical composition comprising the derivative, and an application thereof in preparing medicine for curing cancer. The cancer is a drug-resistant cancer, preferably a cancer resisting an EGFR reversible inhibitor, and more preferably, a cancer resisting gefitinib, erlotinib or lapatinib; alternatively, the cancer carries EGFR mutation.

Synthesis of crescent aromatic oligoamides

This article describes the synthetic procedures for the preparation of crescent (and helical) aromatic oligoamides developed in recent years in our laboratory. The large-scale preparation of a variety of monomers derived from various tetrasubstituted benzenes is presented. Three different strategies for constructing various oligomers consisting of meta- and meta/para-linked benzene residues are discussed. Factors affecting coupling efficiency and yields are analyzed. The developed synthetic methods have provided the basis for the preparation of longer oligomers and for the development of solid-phase synthesis.

N-(3-pyrrolidinyl) benzamide derivative

N-(3-Pyrrodinyl)benzamide derivatives represented by the following general formula (I) which have potent and selective antagonism against dopamine D3 and/or D4 receptor and are useful as a psychotropic, a schizophrenia-treating agent and the like, or a pharmaceutically acceptable salt thereof or a pharmaceutical preparation thereof. STR1

Antibiotic compounds

The present invention relates to carbapenems and provides a compound of the formula (I): STR1 or a pharmaceutically acceptable salt or in vivo hydrolysable ester thereof wherein: R1 is 1-hydroxyethyl, 1-fluoroethyl or hydroxymethyl; R2 is hydrogen or C1-4 alkyl; R3 is hydrogen or C1-4 alkyl; R4 and R5 are the same or different and are selected from hydrogen, halo, cyano, C1-4 alkyl, nitro, hydroxy, carboxy, C1-4 alkoxy, C1-4 alkoxycarbonyl, aminosulphonyl, C1-4 alkylaminosulphonyl, di-C1-4 alkylaminosulphonyl, carbamoyl, C1-4 alkylcarbamoyl, di-C1-4 alkylcarbamoyl, trifluoromethyl, sulphonic acid, amino, C1-4 alkylamino, di-C1-4 alkylamino, C1-4 alkanoylamino, C1-4 alkanoyl(N-C1-4 alkyl)amino, C1-4 alkanesulphonamido and C1-4 alkylS(O)n -- wherein n is zero, one or two: with the proviso that there is no hydroxy or carboxy substituent in a position ortho to the --NR2 --. Processes for their preparation, intermediates in their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.

Cerium(IV)-induced nitration of cinnamic acids. Novel remote electrophilic substitution

The treatment of (E)-3,4-dimethoxycinnamic acid with ceric amonium nitrate in trifluoroacetic acid afforded (E)1,2-dimethoxy-4-nitro-5-(2-nitroethenyl)benzene in 79percent yield.The unusual ipso substitution of the carboxylic acid moiety by a nitro functional center illustrated a new reaction manifold of cerium(IV).Six cinnamic acids were examined to ascertain the generality of the transformation.The bidentate nitrato structure of the metal salt is believed to account for the nitrating ability of this system.

Decarboxylative Nitration of Some Simple Hydroxybenzoic Acids Using Cerium(IV) Ammonium Nitrate

The mechanistic pathways proposed earlier in the Ce(IV) induced decarboxylation of aromatic acids have been examined in the light of new observations made.A simple, non-explosive, easy to control substitute to Bechman and Biermann's decarboxylative nitration is described and a plausible mechanism suggested.