5-(6-Aminopurin-9-yl)-2-(trityloxymethyl)oxolan-3-ol

Base Information

• Chemical Name: 5-(6-Aminopurin-9-yl)-2-(trityloxymethyl)oxolan-3-ol
• CAS No.: 66503-49-9
• Molecular Formula: C29H27 N5 O3
• Molecular Weight: 493.565
• NSC Number: 91772
• DSSTox Substance ID: DTXSID60985127
• Mol file: 66503-49-9.mol

Synonyms:66503-49-9;NSC91772;DTXSID60985127;NSC-91772;9-[2-Deoxy-5-O-(triphenylmethyl)pentofuranosyl]-9H-purin-6-amine

Chemical Property of 5-(6-Aminopurin-9-yl)-2-(trityloxymethyl)oxolan-3-ol

Chemical Property:

• Vapor Pressure: 1.33E-22mmHg at 25°C
• Boiling Point: 733.7°C at 760 mmHg
• Flash Point: 397.6°C
• Density: 1.35g/cm³
• XLogP3: 4.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 7
• Exact Mass: 493.21138974
• Heavy Atom Count: 37
• Complexity: 679

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1C(C(OC1N2C=NC3=C(N=CN=C32)N)COC(C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)O

Technology Process of 5-(6-Aminopurin-9-yl)-2-(trityloxymethyl)oxolan-3-ol

There total 2 articles about 5-(6-Aminopurin-9-yl)-2-(trityloxymethyl)oxolan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

trityl chloride (76-83-5) + 2'-deoxy-D-adenosine (958-09-8,7005-15-4) → 5'-O-trityl-2'-deoxyadenosine (66503-49-9)

Guidance literature:

With pyridine;

Reference yield:

→ 5'-O-trityl-2'-deoxyadenosine (66503-49-9)

Guidance literature:

Detritylierung mit CF3COOH;

DOI:10.1016/S0008-6215(00)83480-1

Reference yield: 96.4%

5'-O-trityl-2'-deoxyadenosine (66503-49-9) + methyl iodide (74-88-4) → 5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine (265987-42-6)

Guidance literature:

With carbon disulfide; sodium hydroxide; In dimethyl sulfoxide;

upstream raw materials:

trityl chloride

2'-deoxy-D-adenosine

Downstream raw materials:

N⁶,O^3'-diacetyl-O^5'-trityl-2'-deoxy-adenosine

4,5-dihydro-5-trityloxymethylfuran-4-one

adenine

5'-O-trityl-3'-O-methylthiothiocarbonyl-2'-deoxy-adenosine